4-甲氧基-3-甲基苯甲酸合成路线 （共 42 条）
参考文献
Baker, Raymond; O'Mahony, Mary J.; Swain, Christopher J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1623 - 1634
反应条件
1: 90 percent / SOCl2 / 24 h / 25 °C
2: CH2Cl2 / 2 h / 25 °C
3: SOCl2 / CH2Cl2 / 0.5 h / 25 °C
4: 1.) sec-butyllithium / 1.) ether, 0 deg C, 4 h; 2.) ether, -78 deg C, 15 min then to r.t.
5: 98 percent / diethyl ether / 0.25 h / 0 °C
6: 88 percent / 3M H2SO4 / tetrahydrofuran / 12 h / 25 °C
View Scheme
参考文献
Baker, Raymond; O'Mahony, Mary J.; Swain, Christopher J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1623 - 1634
反应条件
1: (COCl)2; DMF / CH2Cl2
2: diethyl ether / 0 °C
3: aq. Ag2O / dioxane
4: (COCl)2; DMF / CH2Cl2
View Scheme
参考文献
Young, Jonathan R.; Huang, Song X.; Chen, Irene; Walsh, Thomas F.; DeVita, Robert J.; Wyvratt Jr., Matthew J.; Goulet, Mark T.; Ren, Ning; Lo, Jane; Yang, Yi Tien; Yudkovitz, Joel B.; Cheng, Kang; Smith, Roy G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1723 - 1727
反应条件
Boc-Phe-OH; palladium diacetate; lithium carbonate; silver carbonate; p-benozquinone in tert-butyl alcohol
T=90°C; 12 h; Inert atmosphere; Reagent/catalyst;
参考文献
Rosen, Brandon R.; Simke, Leah R.; Thuy-Boun, Peter S.; Dixon, Darryl D.; Yu, Jin-Quan; Baran, Phil S.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 28 p. 7317 - 7320
Angew. Chem., 2013 , vol. 125, # 28 p. 7458 - 7461,4
参考文献
Smith, Amos B.; Schow, Steven R.; Bloom, Jonathan D.; Thompson, Andrew S.; Winzenberg, Kevin N.
Journal of the American Chemical Society, 1982 , vol. 104, # 14 p. 4015 - 4018
反应条件
chlorine; acetic acid
参考文献
Achenbach,H. et al.
Justus Liebigs Annalen der Chemie, 1977 , p. 1 - 7
反应条件
1: Cl2, AcOH
2: (i) LiAlH4, (ii) HBr
3: NaOEt, 2-nitro-propane
View Scheme
参考文献
Achenbach,H. et al.
Justus Liebigs Annalen der Chemie, 1977 , p. 1 - 7
反应条件
1: Cl2, AcOH
2: (i) LiAlH4, (ii) HBr
3: NaOEt, 2-nitro-propane
4: NaOMe
5: H2 / Pd-C
View Scheme
参考文献
Achenbach,H. et al.
Justus Liebigs Annalen der Chemie, 1977 , p. 1 - 7
反应条件
1: Cl2, AcOH
2: (i) LiAlH4, (ii) HBr
3: NaOEt, 2-nitro-propane
4: NaOMe
5: (i) H2, Pd-C, (ii) LiAlH4
View Scheme
参考文献
Achenbach,H. et al.
Justus Liebigs Annalen der Chemie, 1977 , p. 1 - 7
反应条件
1: Cl2, AcOH
2: (i) LiAlH4, (ii) HBr
3: NaOEt, 2-nitro-propane
4: NaOMe
5: (i) H2, Pd-C, (ii) LiAlH4, (iii) Py*HClCrO3
View Scheme
参考文献
Achenbach,H. et al.
Justus Liebigs Annalen der Chemie, 1977 , p. 1 - 7
