3-氨基-1,4-二甲基-5H-吡啶[4,3-B]吲哚乙酸合成路线 （共 13 条）
反应条件
1: 87 percent / NH2OH*HCl, NaOAc / ethanol / 1 h / Heating 2: 55 percent / xylene / 24 h / Heating 3: 90 percent / 10percent aqueous NaOH / ethanol / 1 h / Heating 4: 82 percent / diphenylphosphoryl azide (DPPA), triethylamine / 0.5 h / 80 °C 5: 81 percent / AcOH / H2O / 1 h / 80 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 22 p. 5917 - 5921
反应条件
1: 55 percent / xylene / 24 h / Heating 2: 90 percent / 10percent aqueous NaOH / ethanol / 1 h / Heating 3: 82 percent / diphenylphosphoryl azide (DPPA), triethylamine / 0.5 h / 80 °C 4: 81 percent / AcOH / H2O / 1 h / 80 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 22 p. 5917 - 5921
反应条件
aluminium trichloride T=100 - 120°C; 12 h;
参考文献
Takeda; Shudo; Okamoto; Kosuge
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 5 p. 1280 - 1285
