1,4-二甲基-1H-吡唑-5-羧酸乙酯合成路线 （共 8 条）
反应条件
1: 92 percent / 1 N aq. NaOH / ethanol / 2 h / Heating 2: SOCl2 / 2 h / Heating View Scheme
参考文献
Huppatz; Phillips; Witrzens
Agricultural and Biological Chemistry, 1984 , vol. 48, # 1 p. 45 - 50
反应条件
sodium hydroxide in ethanol 2 h; Heating;
参考文献
Huppatz; Phillips; Witrzens
Agricultural and Biological Chemistry, 1984 , vol. 48, # 1 p. 45 - 50
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 10 h;
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
Location in patent: Paragraph 0175 ;
反应条件
sodium ethanolate in ethanol
Ambient temperature;
参考文献
Huppatz; Phillips; Witrzens
Agricultural and Biological Chemistry, 1984 , vol. 48, # 1 p. 45 - 50
反应条件
1: hydrazine monohydrochloride / ethanol / 85 °C
2: potassium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C
View Scheme
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
反应条件
diethyl ether
bei 2-taegiger Einwirkung;
参考文献
v.Auwers; Ungemach
Chemische Berichte, 1933 , vol. 66, p. 1209
反应条件
2 h; Heating; Yield givenYields of byproduct given. Title compound not separated from byproducts;
参考文献
Martins, Marcos A. P.; Freitag, Rogerio A.; Da Rosa, Adriano; Flores, Alex F. C.; Zanatta, Nilo; Bonacorso, Helio G.
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 1 p. 217 - 220
反应条件
1: 92 percent / 1 N aq. NaOH / ethanol / 2 h / Heating
2: SOCl2 / 2 h / Heating
3: pyridine / 0.5 h / Heating
View Scheme
参考文献
Huppatz; Phillips; Witrzens
Agricultural and Biological Chemistry, 1984 , vol. 48, # 1 p. 45 - 50
