2H-噻喃-3,5(4H,6H)-二酮合成路线 （共 9 条）
反应条件
sodium methylate; benzene
参考文献
Journal of the American Chemical Society, , vol. 77, p. 4241,4242
反应条件
potassium tert-butylate in tetrahydrofuran T=65°C; 0.25 h; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 17 p. 6792 - 6802
反应条件
1: With pyridine in toluene T=20°C; 3 h; 2: With 4-(N,N-dimethlyamino)pyridine in toluene
参考文献
Zheldakova; Budnikova; Rubinova; Rubinov
Russian Journal of Organic Chemistry, 2003 , vol. 39, # 12 p. 1772 - 1776
反应条件
1: NH2OH*HCl; NaOAc*H2O / ethanol; H2O / 0.5 h
2: 46 percent / SCl2; iodine / tetrahydrofuran / -70 - -40 °C
View Scheme
参考文献
Camilleri, Patrick; Clark, Michael T.; Gilmore, Ian J.; Cole-Hamilton, David
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1985 , p. 833 - 836
反应条件
1: NH2OH*HCl; NaOAc*H2O / ethanol; H2O / 0.5 h
2: 46 percent / SCl2; iodine / tetrahydrofuran / -70 - -40 °C
3: 70 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.25 h / Ambient temperature
View Scheme
参考文献
Camilleri, Patrick; Clark, Michael T.; Gilmore, Ian J.; Cole-Hamilton, David
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1985 , p. 833 - 836
反应条件
1: NH2OH*HCl; NaOAc*H2O / ethanol; H2O / 0.5 h
2: 46 percent / SCl2; iodine / tetrahydrofuran / -70 - -40 °C
3: 64 percent / m-chloroperbenzoic acid / CHCl3 / 2 h / 40 °C
View Scheme
参考文献
Camilleri, Patrick; Clark, Michael T.; Gilmore, Ian J.; Cole-Hamilton, David
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1985 , p. 833 - 836
反应条件
1: 87 percent / 1 h / 0 °C
2: 66 percent / methanol / 1 h / Heating
View Scheme
参考文献
Menozzi, Giulia; Mosti, Luisa; Schenone, Pietro
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1437 - 1440
反应条件
1: 87 percent / 1 h / 0 °C
2: 61 percent / NH2OH*HCl / methanol / 1 h / Heating
View Scheme
参考文献
Menozzi, Giulia; Mosti, Luisa; Schenone, Pietro
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1437 - 1440
参考文献
MOCHIDA PHARMACEUTICAL CO., LTD.
Patent: EP1048640 A1, 2000 ;
