4-(羟基甲基)苯氧基乙酸合成路线 （共 8 条）
反应条件
sodium hydrogencarbonate in water
参考文献
Atherton, Eric; Logan, Christopher J.; Sheppard, Robert C.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 538 - 546
反应条件
sodium hydroxide; water in methanol
参考文献
Bioorganic and Medicinal Chemistry, , vol. 16, # 23 p. 10049 - 10060
反应条件
1: 34 percent / gas. hydrogen chloride / H2O / 0.67 h / -5 °C 2: 53 percent / sodium hydrogen carbonate / H2O View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 538 - 546
反应条件
caesium carbonate in N-methyl-acetamide; water; ethyl acetate
参考文献
Kaken Pharmaceutical Co., Ltd.
Patent: EP1325903 A1, 2003 ;
反应条件
N-ethyl-N,N-diisopropylamine in ethyl acetate; N,N-dimethyl-formamide
参考文献
Hoechst Aktiengesellschaft
Patent: US5565606 A1, 1996 ;
反应条件
dicyclohexyl-carbodiimide in 1,4-dioxane 1.) ice water temp., 60 min; 2.) r.t., 1.75 h;
参考文献
Atherton, Eric; Cameron, Linda R.; Sheppard, Robert C.
Tetrahedron, 1988 , vol. 44, # 3 p. 843 - 858
反应条件
dicyclohexyl-carbodiimide in ethyl acetate
Ambient temperature;
参考文献
Atherton, Eric; Logan, Christopher J.; Sheppard, Robert C.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 538 - 546
