4-氨基-3-硫代氰酰基苯甲腈合成路线 （共 5 条）
反应条件
hydrogenchloride; water T=100°C; 6 h;
参考文献
Institute of Pharmacology and Toxicology Academy of Military Medical Science, P.L.A
Patent: US2011/319423 A1, 2011 ;
Location in patent: Page/Page column 10 ;
反应条件
1.1: hydrogenchloride; water / 6 h / 100 °C 2.1: potassium hydroxide; water / 24 h / Inert atmosphere; Reflux 2.2: Cooling with ice 3.1: sodium carbonate / water / 45 °C / Inert atmosphere 3.2: 45 - 80 °C 3.3: pH 2 - 3 View Scheme
参考文献
Institute of Pharmacology and Toxicology Academy of Military Medical Science, P.L.A
Patent: US2011/319423 A1, 2011 ;
反应条件
1.1: hydrogenchloride; water / 6 h / 100 °C 2.1: potassium hydroxide; water / 24 h / Inert atmosphere; Reflux 2.2: Cooling with ice View Scheme
参考文献
Institute of Pharmacology and Toxicology Academy of Military Medical Science, P.L.A
Patent: US2011/319423 A1, 2011 ;
反应条件
acetic acid
T=20°C; 3.5 h; Cooling with ice;
参考文献
Institute of Pharmacology and Toxicology Academy of Military Medical Science, P.L.A
Patent: US2011/319423 A1, 2011 ;
Location in patent: Page/Page column 9-10 ;
反应条件
bromine in water; acetic acid
T=5°C; 1 h;
参考文献
Caleta; Grdisa; Mrvos-Sermek; Cetina; Tralic-Kulenovic; Pavelic; Karminski-Zamola
Farmaco, 2004 , vol. 59, # 4 p. 297 - 305
