3-(4-氯苯基)-5-甲基-4-异噁唑羧酸甲酯合成路线 （共 7 条）
反应条件
potassium hydroxide in ethanol; water 10 h; Heating;
参考文献
Akiba, Kin-ya; Kashiwagi, Kohichi; Ohyama, Yoshihiko; Yamamoto, Yoshuke; Ohkata, Katsuo
Journal of the American Chemical Society, 1985 , vol. 107, # 9 p. 2721 - 2730
反应条件
lithium aluminium tetrahydride in diethyl ether T=40°C; 1 h;
参考文献
Roy, Amrendra K.; Batra, Sanjay
Synthesis, 2003 , # 9 p. 1347 - 1356
反应条件
(i) Na, MeOH, (ii) /BRN= 1210991/; Multistep reaction;
参考文献
Doyle,F.P. et al.
Journal of the Chemical Society, 1963 , p. 5838 - 5845
反应条件
N-bromosuccinmide
1.) DMF, 10-15 degC, 2 h; 2.) 4 h, 0 degC, 15 h, room t.; Yield given. Multistep reaction;
参考文献
Akiba, Kin-ya; Kashiwagi, Kohichi; Ohyama, Yoshihiko; Yamamoto, Yoshuke; Ohkata, Katsuo
Journal of the American Chemical Society, 1985 , vol. 107, # 9 p. 2721 - 2730
反应条件
triethylamine in diethyl ether
24 h; Ambient temperature;
参考文献
Battioni,P. et al.
Bulletin de la Societe Chimique de France, 1978 , vol. <II>, p. 415 - 427
反应条件
1: NBS / CCl4 / 24 h / 40 - 45 °C / UV-irradiation
2: 80 percent / NH2OH*HCl; NaOAc / methanol / Heating
3: aq. HCl; formaldehyde / 1 h / 20 °C
View Scheme
参考文献
Roy, Amrendra K.; Rajaraman; Batra, Sanjay
Tetrahedron, 2004 , vol. 60, # 10 p. 2301 - 2310
反应条件
1: 75 percent / potassium hydroxide / ethanol; H2O / 10 h / Heating
2: 36 percent / sodium hydroxide, hydrogen / Raney nickel (W2) / H2O / Ambient temperature
View Scheme
参考文献
Akiba, Kin-ya; Kashiwagi, Kohichi; Ohyama, Yoshihiko; Yamamoto, Yoshuke; Ohkata, Katsuo
Journal of the American Chemical Society, 1985 , vol. 107, # 9 p. 2721 - 2730
