2-羟基甲基-2-环戊酮合成路线 （共 25 条）
反应条件
hydrogenchloride; water
Hydrolysis;
参考文献
Jeong, Nakcheol; Hwang, Sung Hee
Angewandte Chemie - International Edition, 2000 , vol. 39, # 3 p. 636 - 638
反应条件
1: DIBAL / toluene / 7 h / -78 °C
2: oxalic acid / CH2Cl2; H2O / 3.5 h / Ambient temperature
View Scheme
参考文献
Smith III; Branca; Pilla; Guaciaro
Journal of Organic Chemistry, 1982 , vol. 47, # 10 p. 1855 - 1869
反应条件
1: 1.) n-BuLi, 2.) / 1.) THF, -78 deg C, 2.) -78 deg C
2: DIBAL / toluene / 7 h / -78 °C
3: oxalic acid / CH2Cl2; H2O / 3.5 h / Ambient temperature
View Scheme
参考文献
Smith III; Branca; Pilla; Guaciaro
Journal of Organic Chemistry, 1982 , vol. 47, # 10 p. 1855 - 1869
反应条件
1: 85 percent / TsOH*H2O / benzene / 43 h / Heating; azeotropic removal of water
2: 1.) n-BuLi, 2.) / 1.) THF, -78 deg C, 2.) -78 deg C
3: DIBAL / toluene / 7 h / -78 °C
4: oxalic acid / CH2Cl2; H2O / 3.5 h / Ambient temperature
View Scheme
参考文献
Smith III; Branca; Pilla; Guaciaro
Journal of Organic Chemistry, 1982 , vol. 47, # 10 p. 1855 - 1869
反应条件
1: 82 percent / fumaric acid / benzene / 68 h / Heating; azeotropic removal of water
2: DIBAL / toluene / 7 h / -78 °C
3: oxalic acid / CH2Cl2; H2O / 3.5 h / Ambient temperature
View Scheme
参考文献
Smith III; Branca; Pilla; Guaciaro
Journal of Organic Chemistry, 1982 , vol. 47, # 10 p. 1855 - 1869
反应条件
2: O3 / CH2Cl2 / -78 °C
View Scheme
参考文献
Smith, Amos B.; Malamas, Michael S.
Journal of Organic Chemistry, 1982 , vol. 47, # 18 p. 3442 - 3447
反应条件
1: Me3Al
2: NaIO4 / H2O; methanol / 72 h / 25 °C
3: toluene / 0.5 h / Heating
View Scheme
参考文献
Itoh, Akira; Ozawa, Shuji; Oshima, Koichiro; Nozaki, Hitosi
Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 1 p. 274 - 278
反应条件
mercury(II) diacetate
Heating;
参考文献
Matlin, Albert R.; Leckta, Thomas C.; McGarvey, David J.; Jacob, Peter W.; Picken, Harold A.
Tetrahedron Letters, 1987 , vol. 28, # 43 p. 5083 - 5086
参考文献
Smith III; Branca; Pilla; Guaciaro
Journal of Organic Chemistry, 1982 , vol. 47, # 10 p. 1855 - 1869
参考文献
Smith III; Pilla
Tetrahedron Letters, 1980 , vol. 21, # 49 p. 4691 - 4694
