N2-异丁酰-5'-O-(4,4'-二甲氧基三苯基)-2'-脱氧鸟苷合成路线 （共 21 条）
反应条件
1: pyridine / 2 h 2: aq. NH4OH / pyridine / 0.5 h 3: 72 percent / DMAP, TEA / pyridine / 1 h View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 32, # 9 p. 916 - 919
反应条件
lithium triethylborohydride in tetrahydrofuran 16 h; cooling;
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 23, # 1-2 p. 171 - 181
反应条件
pyridine T=20°C; 3 h;
参考文献
EP1253154 A1, ;
Example 1 ;
反应条件
N-ethyl-N,N-diisopropylamine; trifluoroacetic acid in tetrahydrofuran T=20°C; 12 h; Product distribution / selectivity;
参考文献
Werner, Christian; Nerenz, Frank; Kanschik-Conradsen, Andreas; Reddy, Kalakota
Patent: US2003/232980 A1, 2003 ;
Location in patent: Page 6 ;
反应条件
pyridine in dichloromethane T=20°C; 0.0833333 h; Large scale reaction;
参考文献
Janczyk, Matthaeus; Appel, Bettina; Springstubbe, Danilo; Fritz, Hans-Joachim; Mueller, Sabine
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 8 p. 1510 - 1513
反应条件
in tetrahydrofuran according to ref 3) with modifications;
参考文献
Sinha, N. D.; Biernat, J.; Koester, H.
Tetrahedron Letters, 1983 , vol. 24, # 52 p. 5843 - 5846
反应条件
4-(N,N-dimethlyamino)pyridine in pyridine
参考文献
Le Bec, Christine; Wickstrom, Eric
Tetrahedron Letters, 1994 , vol. 35, # 51 p. 9525 - 9528
反应条件
iodine in methanol T=60°C; detritylation;
参考文献
Wahlstrom, Jan L.; Ronald, Robert C.
Journal of Organic Chemistry, 1998 , vol. 63, # 17 p. 6021 - 6022
反应条件
ammonium hydroxide in 1,4-dioxane
72 h;
参考文献
Gryaznov; Schultz
Tetrahedron Letters, 1994 , vol. 35, # 16 p. 2489 - 2492
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran
Ambient temperature;
参考文献
Adams, Steven P.; Kavka, Kamila S.; Wykes, Evan J.; Holder, Sarah B.; Galluppi, Gerald R.
Journal of the American Chemical Society, 1983 , vol. 105, # 3 p. 661 - 663
