2-甲基-4-甲氧基吡啶-N-物合成路线 （共 16 条）
反应条件
in methanol
3 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/56886 A1, 2009 ;
Location in patent: Page/Page column 54-55 ;
WO 2009/056886 A1
反应条件
1: H2SO4; HNO3
View Scheme
参考文献
Henson, Mark J.; Vance, Michael A.; Zhang, Christiana Xin; Hong-Chang, Liang; Karlin, Kenneth D.; Solomon, Edward I.
Journal of the American Chemical Society, 2003 , vol. 125, # 17 p. 5186 - 5192
反应条件
1: 98 percent / conc. H2SO4, 65percent HNO3 / 22 h / 95 °C
2: 100 percent / K2CO3 / 12 h / Heating
View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
in acetonitrile
T=24.84°C; Equilibrium constant;
参考文献
Rubachenko; Schroeder; Chotii; Kovalenko; Red'ko; Lenska
Russian Journal of General Chemistry, 2008 , vol. 78, # 6 p. 1241 - 1246
反应条件
1: 2 h / 90 °C
2: 2 N aq. NaOH / 2 h / 80 °C
3: SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
4: 2 N aq. NaOH / ethanol / 2 h / 50 °C
5: 94 percent / 10percent aq. NaOCl, 6 N aq. NaOH / ethyl acetate / 0.5 h
View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
1: 4 h / 100 °C
2: 2 M NaOH / 1 h / 100 °C
3: 100 percent / SOCl2 / CH2Cl2 / 2 h
View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
