(2E)-3-(1-甲基-1H-吡唑-4-基)丙烯酸合成路线 （共 2 条）
反应条件
1: With piperidine; pyridine
T=110°C; 4 h; Inert atmosphere;
2: With hydrogenchloride in water
pH=1;
参考文献
GLAXO GROUP LIMITED; JIN, Yun; WAN, Zehong; ZHANG, Qing
Patent: WO2012/76435 A1, 2012 ;
Location in patent: Page/Page column 29 ;
反应条件
1: With potassium hydroxide in methanol
T=70°C;
2: With hydrogenchloride in water
pH=4;
参考文献
REPLIGEN CORPORATION; JACQUES, Vincent; RUSCHE, James R.; PEET, Norton P.; SINGH, Jasbir
Patent: WO2012/118782 A1, 2012 ;
Location in patent: Page/Page column 75 ;
WO 2012/118782 A1
