2-溴-6-(氯甲基)-萘合成路线 (共 7 条)
反应条件
1: 97 percent / H2O; acetonitrile / Heating 2: 93 percent / aq. AcOH / H2SO4 / Heating View Scheme
参考文献
Pu, Yu-Ming; Ku, Yi-Yin; Grieme, Timothy; Black, Lawrence A.; Bhatia, Ashok V.; Cowart, Marion
Organic Process Research and Development, 2007 , vol. 11, # 6 p. 1004 - 1009
反应条件
in water; acetonitrile Heating;
参考文献
Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-Jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Sharma, Padam N.; Bennani, Youssef L.
Patent: US2004/92521 A1, 2004 ;
Location in patent: Page/Page column 30 ;
US 20040092521 A1
反应条件
in water; acetonitrile Reflux;
参考文献
Zhao, Wenjun; Huang, Li; Guan, Yong; Wulff, William D.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 13 p. 3436 - 3441
Angew. Chem., 2014 , vol. 126, # 13 p. 3504 - 3509,6
反应条件
thionyl chloride; zinc(II) chloride in 1,4-dioxane
T=-10°C;
参考文献
Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-Jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Sharma, Padam N.; Bennani, Youssef L.
Patent: US2004/92521 A1, 2004 ;
Location in patent: Page/Page column 30 ;
US 20040092521 A1
反应条件
1: 95 percent / LAH / tetrahydrofuran / -10 °C
2: 99 percent / SOCl2; ZnCl2 / dioxane / -10 °C
View Scheme
参考文献
Black, Lawrence A.; Nersesian, Diana L.; Sharma, Padam; Ku, Yi-Yin; Bennani, Youssef L.; Marsh, Kennan C.; Miller, Thomas R.; Esbenshade, Timothy A.; Hancock, Arthur A.; Cowart, Marlon
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1443 - 1446
反应条件
1: DIBAL / tetrahydrofuran / 18 h / 0 - 20 °C
2: ZnCl2, SOCl2 / dioxane / 0.67 h
View Scheme
参考文献
Ellingboe, John W.; Lombardo, Louis J.; Alessi, Thomas R.; Nguyen, Thomas T.; Guzzo, Frieda; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 17 p. 2485 - 2493
反应条件
1: 97 percent / H2O; acetonitrile / Heating
2: 93 percent / aq. AcOH / H2SO4 / Heating
3: 96 percent / BH3*THF / tetrahydrofuran / -15 °C
View Scheme
参考文献
Pu, Yu-Ming; Ku, Yi-Yin; Grieme, Timothy; Black, Lawrence A.; Bhatia, Ashok V.; Cowart, Marion
Organic Process Research and Development, 2007 , vol. 11, # 6 p. 1004 - 1009