copper dichloride; palladium dichloride in 1,4-dioxane T=80°C; 12 h; Title compound not separated from byproducts;

hydrogenchloride T=100°C; 1 h;

palladium diacetate; triethylamine; triphenylphosphine; silver nitrate in acetonitrile T=80°C; Heck cyclization; 8 h;

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / cooling 1.2: 60 percent / hexane; tetrahydrofuran / 0.5 h / 20 °C 2.1: CuCl2 / PdCl2 / dioxane / 12 h / 80 °C View Scheme

1.1: diethyl zinc; trifluoroacetic acid / CH2Cl2; hexane / 20 h / cooling 1.2: 93 percent / CH2Cl2; hexane / 0.5 h / cooling 2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / cooling 2.2: 60 percent / hexane; tetrahydrofuran / 0.5 h / 20 °C 3.1: CuCl2 / PdCl2 / dioxane / 12 h / 80 °C View Scheme

sodium carbonate; triethylamine; palladium dichloride; Tl(OCOCF3)3 Yield given. Multistep reaction;

sodium carbonate; triethylamine; palladium dichloride; Tl(OCOCF3)3 Yield given. Multistep reaction;