3-(4,4-二甲基-4,5-二氢-1,3-噁唑)-4-甲基吡啶合成路线 （共 10 条）
反应条件
1: 99 percent / tetrahydrofuran / 1 h / -78 °C 2: 90 percent / O2 / diethyl ether / 0.25 h View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 65, p. 648 - 655
反应条件
oxygen in diethyl ether 0.25 h;
参考文献
Binay, P.; Dupas, G.; Bourguignon, J.; Queguiner, G.
Canadian Journal of Chemistry, 1987 , vol. 65, p. 648 - 655
反应条件
air; chloranil in tetrahydrofuran; diethyl ether 0.5 h;
参考文献
Meyers, A. I.; Gabel, Richard A.
Journal of Organic Chemistry, 1982 , vol. 47, # 13 p. 2633 - 2637
反应条件
1: thionyl chloride / 24 h 3: 100 percent / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) 0 deg C, 1 h 4: 73 percent / chloranil, air / diethyl ether; tetrahydrofuran / 0.5 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 13 p. 2633 - 2637
反应条件
2: 100 percent / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) 0 deg C, 1 h 3: 73 percent / chloranil, air / diethyl ether; tetrahydrofuran / 0.5 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 13 p. 2633 - 2637
反应条件
1: 75.9 percent / 2.5 h / Heating 2: 69.3 percent / diethyl ether / 1 h / Ambient temperature 3: 52.3 percent / oxygen / benzene / 10 h / Ambient temperature; other reagents, solvents, time View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2070 - 2076
反应条件
water; oxygen 1.) ether, room temperature, 1 h, 2.) 0 deg C; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 10 p. 2227 - 2232
反应条件
1: 72 percent / conc. aq. HCl / 18 h / Heating 2: SOCl2 / 2 h / Heating 3: CH2Cl2 / Ambient temperature View Scheme
参考文献
Moos; Bergmeier; Coughenour; Davis; Hershenson; Kester; McKee; Marriott; Schwarz; Tecle; Thomas
Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 10 p. 1015 - 1019
反应条件
hydrogenchloride 18 h; Heating;
参考文献
Moos; Bergmeier; Coughenour; Davis; Hershenson; Kester; McKee; Marriott; Schwarz; Tecle; Thomas
Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 10 p. 1015 - 1019
反应条件
1: 72 percent / conc. aq. HCl / 18 h / Heating 2: SOCl2 / 2 h / Heating View Scheme
参考文献
Moos; Bergmeier; Coughenour; Davis; Hershenson; Kester; McKee; Marriott; Schwarz; Tecle; Thomas
Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 10 p. 1015 - 1019
