N-(6-碘咪唑并[1,2-a]吡啶-2-基)乙酰胺合成路线 （共 6 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
T=20°C; 5 h;
参考文献
NOVARTIS AG
Patent: WO2007/95588 A1, 2007 ;
Location in patent: Page/Page column 63-64 ;
WO 2007/095588 A1
反应条件
2.5 h; Heating / reflux;
参考文献
MERCK and CO., INC.
Patent: WO2004/43940 A1, 2004 ;
Location in patent: Page 83 ;
反应条件
1: pyridine / 16 h / 20 °C
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C
3: dichloromethane / 16 h / Reflux
4: sodium hydroxide / 16 h / 20 °C
5: acetic acid / 16 h / 20 °C
View Scheme
参考文献
Hughes, Samantha J.; Millan, David S.; Kilty, Iain C.; Lewthwaite, Russell A.; Mathias, John P.; Reilly, Mark A.O.; Pannifer, Andrew; Phelan, Anne; Stuehmeier, Frank; Baldock, Darren A.; Brown, David G.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6586 - 6590
反应条件
1: dichloromethane / 16 h / Reflux
2: sodium hydroxide / 16 h / 20 °C
3: acetic acid / 16 h / 20 °C
View Scheme
参考文献
Hughes, Samantha J.; Millan, David S.; Kilty, Iain C.; Lewthwaite, Russell A.; Mathias, John P.; Reilly, Mark A.O.; Pannifer, Andrew; Phelan, Anne; Stuehmeier, Frank; Baldock, Darren A.; Brown, David G.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6586 - 6590
反应条件
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C
2: dichloromethane / 16 h / Reflux
3: sodium hydroxide / 16 h / 20 °C
4: acetic acid / 16 h / 20 °C
View Scheme
参考文献
Hughes, Samantha J.; Millan, David S.; Kilty, Iain C.; Lewthwaite, Russell A.; Mathias, John P.; Reilly, Mark A.O.; Pannifer, Andrew; Phelan, Anne; Stuehmeier, Frank; Baldock, Darren A.; Brown, David G.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6586 - 6590
反应条件
1: sodium hydroxide / 16 h / 20 °C
2: acetic acid / 16 h / 20 °C
View Scheme
参考文献
Hughes, Samantha J.; Millan, David S.; Kilty, Iain C.; Lewthwaite, Russell A.; Mathias, John P.; Reilly, Mark A.O.; Pannifer, Andrew; Phelan, Anne; Stuehmeier, Frank; Baldock, Darren A.; Brown, David G.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6586 - 6590
