2,3-二氯-5-三氟甲基吡啶合成路线 （共 43 条）
参考文献
Ishihara Sangyo Kaisha, Ltd.
Patent: US4331670 A1, 1982 ;
反应条件
acetic acid; zinc in water T=90°C; 1.25 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/94822 A1, 2005 ;
Location in patent: Page/Page column 28 ;
WO 2005/094822 A1
反应条件
hydrazine hydrate in ethanol T=40°C; 24 h;
参考文献
Haga, Takahiro; Fujikawa, Kan-ichi; Koyanagi, Tohru; Nakajima, Toshio; Hayashi, Kouji
Heterocycles, 1984 , vol. 22, # 1 p. 117 - 124
反应条件
potassium carbonate in N,N-dimethyl-formamide T=140°C; Substitution; 30 h;
参考文献
Sakamoto, Noriyasu; Kurita, Yasuyuki; Yanagi, Kazunori; Matsuo, Noritada
Journal of Organic Chemistry, 2000 , vol. 65, # 4 p. 1225 - 1226
反应条件
1: 2,3-dichloro-5-(trifluoromethyl)-pyridine With 4-(N,N-dimethlyamino)pyridine in anhydrous propionitrile Heating / reflux; 2: sodium cyanide in water; anhydrous propionitrile 5 h;
参考文献
WO2008/118718 A2, ;
Page/Page column 76 ;
反应条件
1: 2,3-dichloro-5-(trifluoromethyl)-pyridine With 4-(N,N-dimethlyamino)pyridine in anhydrous propionitrile 5 h; Heating / reflux; 2: sodium cyanide in water T=15°C; 5 h;
参考文献
US6699993 B1, ;
Page column 4 ;
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile T=84°C; 10 h; Conversion of starting material;
参考文献
US6699993 B1, ;
Page column 3 ;
反应条件
4-(N,N-dimethlyamino)pyridine in anhydrous propionitrile T=98°C; 4 h; Conversion of starting material;
参考文献
US6699993 B1, ;
Page column 3 ;
反应条件
potassium carbonate in water; dimethyl sulfoxide
参考文献
The Dow Chemical Company
Patent: US4910309 A1, 1990 ;
参考文献
Tosoh Corporation; Agro-Kanesho Co., Ltd.
Patent: US4948421 A1, 1990 ;
