2,3-二氯-5-三氟甲基吡啶合成路线 （共 43 条）
反应条件
potassium carbonate; cesium fluoride in 1-methyl-pyrrolidin-2-one T=110 - 120°C; P=18.7519 - 22.5023 Torr; 15 - 24 h; Product distribution / selectivity;
参考文献
Pfleger, Christophe; Waldmeier, Pius; Wang, Shaoning
Patent: US2008/221327 A1, 2008 ;
Location in patent: Page/Page column 6; 9 ;
参考文献
Okada; Koyanagi; Yamada; Haga
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2308 - 2315
参考文献
Suntory Limited
Patent: US4976773 A1, 1990 ;
反应条件
trimethylsilyl bromide T=100°C; 15 h; Inert atmosphere;
参考文献
Tsoung, Jennifer; Panteleev, Jane; Tesch, Matthias; Lautens, Mark
Organic Letters, 2014 , vol. 16, # 1 p. 110 - 113
反应条件
potassium hydroxide; water; thiourea 1) ethanol, reflux, 3h, 2) ethanol, reflux, 1h; Yield given. Multistep reaction;
参考文献
Haga, Takahiro; Fujikawa, Kan-ichi; Koyanagi, Tohru; Nakajima, Toshio; Hayashi, Kouji
Heterocycles, 1984 , vol. 22, # 1 p. 117 - 124
反应条件
potassium carbonate; cesium fluoride in dimethyl sulfoxide T=120°C; P=18.7519 - 22.5023 Torr; 4 h; Product distribution / selectivity;
参考文献
Pfleger, Christophe; Waldmeier, Pius; Wang, Shaoning
Patent: US2008/221327 A1, 2008 ;
Location in patent: Page/Page column 9-10 ;
反应条件
potassium hydroxide in tert-butyl alcohol 1 h; Heating;
参考文献
Haga, Takahiro; Fujikawa, Kan-ichi; Koyanagi, Tohru; Nakajima, Toshio; Hayashi, Kouji
Heterocycles, 1984 , vol. 22, # 1 p. 117 - 124
反应条件
in N,N-dimethyl-formamide T=70°C;
参考文献
AMGEN INC.
Patent: WO2007/62175 A2, 2007 ;
Location in patent: Page/Page column 26 ;
WO 2007/062175 A2
反应条件
triethylamine in methanol; methanolic H2SO4(1.9M H2SO4in MeOH, 50 ml); dichloromethane; cyclohexane; ethyl acetate
参考文献
Applied Research Systems ARS Holding N.V.
Patent: EP1088822 A1, 2001 ;
反应条件
1: methanol / 3 h / 100 - 104 °C 2: 13.8 g / H2SO4 / 1.5 h / Heating View Scheme
参考文献
Rueckle, Thomas; Biamonte, Marco; Grippi-Vallotton, Tania; Arkinstall, Steve; Cambet, Yves; Camps, Montserrat; Chabert, Christian; Church, Dennis J.; Halazy, Serge; Jiang, Xuliang; Martinou, Isabelle; Nichols, Anthony; Sauer, Wolfgang; Gotteland, Jean-Pierre
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6921 - 6934
