2,3-二氯-5-三氟甲基吡啶合成路线 （共 43 条）
反应条件
triethylamine in acetonitrile T=40°C; 4.58333 h;
参考文献
Sinochem Corporation; Shenyang Research Institute of Chemical Industry Co., Ltd.
Patent: EP2281810 A1, 2011 ;
Location in patent: Page/Page column 40-41 ;
反应条件
1: With potassium hydroxide in 1-methyl-pyrrolidin-2-one T=70°C; 3 h; 2: With hydrogenchloride in 1-methyl-pyrrolidin-2-one; water T=130°C; pH=2; 2 h;
参考文献
Bayer CropScience S.A.
Patent: EP1674455 A1, 2006 ;
Location in patent: Page/Page column 16 ;
反应条件
1: t-BuOK / tetrahydrofuran 2: TFA View Scheme
参考文献
Huang, Charles Q.; Wilcoxen, Keith M.; Grigoriadis, Dimitri E.; McCarthy, James R.; Chen, Chen
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 3943 - 3947
反应条件
sodium hydroxide in N,N-dimethyl acetamide T=20 - 70°C; 3 h; Product distribution / selectivity;
参考文献
Lhermitte, Frederic; Coqueron, Pierre-Yves; Desbordes, Philippe; HImmler, Thomas
Patent: US2008/86008 A1, 2008 ;
Location in patent: Page/Page column 12 ;
反应条件
sodium hydride in N,N-dimethyl-formamide Ambient temperature;
参考文献
Qian, Xuhong; Liu, Shuyou
Journal of Fluorine Chemistry, 1996 , vol. 79, # 1 p. 9 - 12
反应条件
1: tetrabutylammomium bromide; potassium carbonate / toluene; anhydrous propionitrile / 22 h / Inert atmosphere; Reflux 2: hydrogenchloride; water / toluene / 20 °C / Inert atmosphere 3: hydrogenchloride / water / 5 h / Reflux; Inert atmosphere View Scheme
参考文献
Zhang, Yu-Juan; Shen, Liu-Lan; Cheon, Hyae-Gyeong; Xu, Yong-Nan; Jeong, Jin-Hyun
Archives of Pharmacal Research, 2014 , vol. 37, # 5 p. 588 - 599
反应条件
sodium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride T=120°C; P=11251.1 Torr; 18 h;
参考文献
Roche Palo Alto LLC
Patent: US2009/143589 A1, 2009 ;
Location in patent: Page/Page column 4-5 ;
US 20090143589 A1
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium acetate; 1,4-di(diphenylphosphino)-butane T=120°C; P=11400.8 Torr; 2 h; Autoclave;
参考文献
Crettaz, Roger; Waser, Jerome; Bessard, Yves
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 572 - 574
反应条件
potassium carbonate in dimethyl sulfoxide
参考文献
Suntory Limited
Patent: US4976773 A1, 1990 ;
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C
1.2: 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C
2.2: 0 - 20 °C
3.1: hydrogen bromide; acetic acid / 3.5 h / 110 °C
4.1: hydrazine hydrate / ethanol / 3 h / 80 °C
View Scheme
参考文献
Fodor, Elena; Maftei, Catalin-Vasile; Mangalagiu, Ionel; Jones, Peter G.; Daniliuc, Constantin-Gabriel; Franz, M. Heiko; Neda, Ion
Revue Roumaine de Chimie, 2010 , vol. 55, # 9 p. 559 - 564
