(6-碘苯并[1,3]二氧杂环戊烯-5-基)甲醇合成路线 （共 16 条）
反应条件
1: 20percent aq. HCl / methanol; benzene / 16 h
2: 97 percent / NaBH4 / propan-2-ol / 16 h / Heating
View Scheme
参考文献
Bogucki; Charlton
Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 588 - 593
反应条件
in dimethyl sulfoxide
T=150°C;
参考文献
Kobayashi, Shigeru; Imakura, Yasuhiro; Horikawa, Ritsuko
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 4 p. 1287 - 1293
反应条件
thionyl chloride; triethylamine in benzene
2 h; Ambient temperature;
参考文献
Abelman, Matthew M.; Overman, Larry E.; Tran, Vinh D.
Journal of the American Chemical Society, 1990 , vol. 112, # 19 p. 6959 - 6964
反应条件
pyridinium chlorochromate in dichloromethane
T=0 - 25°C;
参考文献
Padwa; Brodney; Lynch
Journal of Organic Chemistry, 2001 , vol. 66, # 5 p. 1716 - 1724
反应条件
1: 93 percent / pyridinium chlorochromate / CH2Cl2 / 16 h / 18 °C
2: 88 percent / acetic acid; sodium cyanide; MnO2 / CHCl3 / 16 h / 18 °C
View Scheme
参考文献
Matveenko, Maria; Kokas, Okanya J.; Banwell, Martin G.; Willis, Anthony C.
Organic Letters, 2007 , vol. 9, # 18 p. 3683 - 3685
反应条件
1: 80 percent / PBr3; pyridine / diethyl ether / -20 °C
2: 98 percent / NaN3 / dimethylformamide
3: 89 percent / PPh3; water / tetrahydrofuran
4: 29 percent / air / Pd(PPh3)4 / dimethylformamide / 0.58 h / 100 °C
View Scheme
参考文献
Knoelker, Hans-Joachim; Filali, Salima
Synlett, 2003 , # 11 p. 1752 - 1754
