6-溴-4-氧代螺[苯并二氢吡喃-2,4-哌啶]-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
pyrrolidine in methanol T=60 - 65°C; 3 h;
参考文献
Solvay Pharmaceuticalss GmbH
Patent: US2007/117823 A1, 2007 ;
Location in patent: Page/Page column 13 ;
反应条件
1: 5'-bromo-2'-hydroxyacetophenone With pyrrolidine in methanol 2: tert-butyl 4-oxo-piperidine-1-carboxylate in methanol T=80°C;
参考文献
CEPHALON, INC.; PHARMACOPEIA, INC.
Patent: WO2009/97567 A1, 2009 ;
Location in patent: Page/Page column 62 ;
WO 2009/097567 A1
反应条件
hydrogenchloride; methanol
T=10 - 15°C;
参考文献
Iino, Tomoharu; Jona, Hideki; Shibata, Jun; Shimamura, Tadashi; Yamakawa, Takeru; Yang, Lihu
Patent: US2008/171761 A1, 2008 ;
Location in patent: Page/Page column 42 ;
