4-(羟甲基)苯甲酸甲酯合成路线 （共 132 条）
反应条件
potassium hydroxide in methanol Heating;
参考文献
Kita, Yasuyuki; Akai, Shuji; Ajimura, Naomi; Yoshigi, Mayumi; Tsugoshi, Teruhisa; et al.
Journal of Organic Chemistry, 1986 , vol. 51, # 22 p. 4150 - 4158
反应条件
N,N-bis-2-(hydroxyethyl)-2-amino ethane sulfonic acid; lipase from Ophiostoma piliferum in water T=25°C; pH=7.20; Enzyme kinetics;
参考文献
Liu, Andrew Man Fai; Somers, Neil A.; Kazlauskas, Romas J.; Brush, Terry S.; Zocher, Frank; Enzelberger, Markus M.; Bornscheuer, Uwe T.; Horsman, Geoff P.; Mezzetti, Alessandra; Schmidt-Dannert, Claudia; Schmid, Rolf D.
Tetrahedron Asymmetry, 2001 , vol. 12, # 4 p. 545 - 556
反应条件
manganese(IV) oxide; potassium carbonate in tetrahydrofuran; methanol T=20°C;
参考文献
Quesada, Ernesto; Raw, Steven A.; Reid, Mark; Roman, Estelle; Taylor, Richard J.K.
Tetrahedron, 2006 , vol. 62, # 28 p. 6673 - 6680
反应条件
1: MnO2 / tetrahydrofuran / 4 h / 20 °C 2: 23 mg / K2CO3 / tetrahydrofuran; methanol / 20 °C View Scheme
参考文献
Quesada, Ernesto; Taylor, Richard J.K.
Tetrahedron Letters, 2005 , vol. 46, # 38 p. 6473 - 6476
反应条件
1: 4-hydroxymethyl-benzoic acid methylester With methanesulfonyl chloride; triethylamine in dichloromethane T=0 - 20°C; 15 h; 2: potassium cyanide With 18-crown-6 ether in acetonitrile T=20°C; 40 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1577302 A1, 2005 ;
Location in patent: Page/Page column 117 ;
反应条件
triethylamine in dichloromethane; acetonitrile
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1104754 A1, 2001 ;
反应条件
[Ru(II)(η6-benzene)(μ-Cl)Cl]2; 2-((di-p-tolylphosphino)methyl)-1-methyl-1H-imidazole; potassium tert-butylate; hydrogen in tetrahydrofuran T=100°C; P=37503.8 Torr; 4.5 h;
参考文献
Junge, Kathrin; Wendt, Bianca; Westerhaus, Felix Alexander; Spannenberg, Anke; Jiao, Haijun; Beller, Matthias
Chemistry - A European Journal, 2012 , vol. 18, # 29 p. 9011 - 9018
反应条件
1: 98 percent / aq. KOH / methanol / Heating 2: 65 percent / imidazole / dimethylformamide View Scheme
参考文献
Kita, Yasuyuki; Akai, Shuji; Ajimura, Naomi; Yoshigi, Mayumi; Tsugoshi, Teruhisa; et al.
Journal of Organic Chemistry, 1986 , vol. 51, # 22 p. 4150 - 4158
反应条件
1: 71 percent / DMAP; Et3N / acetonitrile / 0.75 h 2: 71 percent / LiAlH4 / diethyl ether / 2 h / Heating 3: 62 percent / O2; NaOAc*3H2O / (neocuproine)Pd(OAc)2 / H2O; dimethylsulfoxide / 4 h / 80 °C / 22502.3 Torr View Scheme
参考文献
Chen, Li; Tilley, Jefferson W.; Guthrie, Robert W.; Mennona, Francis; Huang, Tai-Nan; Kaplan, Gerry; Trilles, Richard; Miklowski, Dorota; Huby, Nicolas; Schwinge, Virginia; Wolitzky, Barry; Rowan, Karen
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 8 p. 729 - 733
反应条件
1: 96 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 18 h / Ambient temperature 2: 80 percent / aq. KOH / methanol / 1 h / Heating View Scheme
参考文献
Kita, Yasuyuki; Akai, Shuji; Ajimura, Naomi; Yoshigi, Mayumi; Tsugoshi, Teruhisa; et al.
Journal of Organic Chemistry, 1986 , vol. 51, # 22 p. 4150 - 4158
