4-(羟甲基)苯甲酸甲酯合成路线 （共 132 条）
反应条件
hydrogenchloride in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
The Dupont Merck Pharmaceutical Company
Patent: US5879657 A1, 1999 ;
反应条件
hydrogenchloride in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
Bristol-Myers Squibb Pharma Company
Patent: EP1293214 A2, 2003 ;
反应条件
1: 96.8 percent / H2SO4 / diethyl ether / Ambient temperature 2: 90 percent / 0.8 M LiOH / methanol; H2O View Scheme
参考文献
Han; Janda
Journal of the American Chemical Society, 1996 , vol. 118, # 11 p. 2539 - 2544
反应条件
rhenic(VII) acid in toluene 24 h; Reflux;
参考文献
Tetrahedron Letters, , vol. 53, # 46 p. 6205 - 6208,4
反应条件
sodium hypochlorite in ethylene glycol dimethyl ether; water T=20°C; 4 h;
参考文献
Synlett, , vol. 24, # 11 art. no. ST-2013-U0273-L, p. 1438 - 1442
反应条件
air; poly-alkylated (nitrosyl)Ru(salen) in toluene T=20°C; 24 h; Irradiation;
参考文献
Miyata, Atsushi; Murakami, Masakazu; Irie, Ryo; Katsuki, Tsutomu
Tetrahedron Letters, 2001 , vol. 42, # 40 p. 7067 - 7070
反应条件
oxygen; sodium acetate; (neocuproine)Pd(OAc)2 in water; dimethyl sulfoxide T=80°C; P=22502.3 Torr; 4 h;
参考文献
Ten Brink, Gerd-Jan; Arends, Isabel W. C. E.; Hoogenraad, Marcel; Verspui, Goeran; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2003 , vol. 345, # 12 p. 1341 - 1352
反应条件
potassium carbonate; chlorobenzene; 2-dicyclohexylphosphino-1,1'-biphenyl; bis(dibenzylideneacetone)-palladium(0) in toluene T=100°C; 12 h;
参考文献
Bei, Xiaohong; Hagemeyer, Alfred; Volpe, Anthony; Saxton, Robert; Turner, Howard; Guram, Anil S.
Journal of Organic Chemistry, 2004 , vol. 69, # 25 p. 8626 - 8633
反应条件
cadmium(II) sulphide in acetonitrile T=20°C; P=37.5038 Torr; 24 h; Inert atmosphereIrradiation;
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 17 p. 3556 - 3561
反应条件
2,4,6-trimethyl-pyridine; trichloromonobromomethane T=60°C; Alkylation;
参考文献
Tetrahedron Letters, , vol. 41, # 32 p. 6249 - 6252
