4-(羟甲基)苯甲酸甲酯合成路线 （共 132 条）
反应条件
carbon tetrabromide; oxygen T=20°C; 20 h; Irradiation;
参考文献
Tetrahedron Letters, , vol. 53, # 39 p. 5306 - 5308
反应条件
Cu(ClO4)2*6H2O; trimethylsilylazide; 2,3-dicyano-5,6-dichloro-p-benzoquinone in 1,2-dichloro-ethane T=60°C; 15 h;
参考文献
Chemical Communications, , vol. 48, # 44 p. 5506 - 5508
反应条件
sulfuric acid in water; acetone
参考文献
ICI Americas Inc.
Patent: US4923890 A1, 1990 ;
US 4923890 A
反应条件
sodium hypochlorite in ethylene glycol dimethyl ether; water T=20°C; 4 h;
参考文献
Synlett, , vol. 24, # 11 art. no. ST-2013-U0273-L, p. 1438 - 1442
反应条件
1: 3-buten-2-yl acetate With di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; (S)-C3-TunePhos; 4-CN-3-NO2-BzOH; caesium carbonate in tetrahydrofuran T=90°C; 0.5 h; Inert atmosphere; 2: 4-hydroxymethyl-benzoic acid methylester in tetrahydrofuran T=90°C; 48 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 131, # 7 p. 2514 - 2520
反应条件
1: 100 percent 2: 88 percent / LiAlH4 / diethyl ether; diethyl ether / 1 h / Heating 3: 87 percent 4: 70 percent / 31percent aq. H2SiF6, Et3N / acetonitrile / 1 h / 0 °C View Scheme
参考文献
Pilcher, Anthony S.; Hill, David K.; Shimshock, Stephen J.; Waltermire, Robert E.; DeShong, Philip
Journal of Organic Chemistry, 1992 , vol. 57, # 8 p. 2492 - 2495
反应条件
carbonylchlorohydridetris(triphenylphosphine) ruthenium(II); ammonia; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,1-dimethylpropan-1-ol T=130°C; 20 h; Inert atmosphereCooling;
参考文献
EVONIK DEGUSSA GmbH; Klasovsky, Florian; Tacke, Thomas; Pfeffer, Jan Christoph; Haas, Thomas; Beller, Matthias; Martin, Andreas; Deutsch, Jens; Koeckritz, Angela; Imm, Sebastian; Haberland, Juergen
Patent: US2013/331580 A1, 2013 ;
Location in patent: Paragraph 0063 ;
反应条件
carbon tetrabromide; triphenylphosphine in benzene T=0°C; 2 h;
参考文献
Barrero, Alejandro F.; Herrador, M. Mar; Del Moral, Jose F. Quilez; Arteaga, Pilar; Akssira, Mohammed; El Hanbali, Fadwa; Arteaga, Jesus F.; Dieguez, Horacio R.; Sanchez, Elena M.
Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 2251 - 2254
反应条件
triphenylphosphine in diethyl ether
参考文献
E. I. Du Pont de Nemours and Company
Patent: US5006524 A1, 1991 ;
反应条件
1: 71 percent / DMAP; Et3N / acetonitrile / 0.75 h 2: 71 percent / LiAlH4 / diethyl ether / 2 h / Heating View Scheme
参考文献
Pilcher, Anthony S.; Hill, David K.; Shimshock, Stephen J.; Waltermire, Robert E.; DeShong, Philip
Journal of Organic Chemistry, 1992 , vol. 57, # 8 p. 2492 - 2495
