4-(羟甲基)苯甲酸甲酯合成路线 （共 132 条）
参考文献
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL, RESEARCH ORGANISATION
Patent: EP333758 B1, 1995 ;
反应条件
1.1: N,N,N',N'-tetra-methylnaphthalene-1,8-diamine / dichloromethane / 24 h / 20 °C / |Inert atmosphere 2.1: ammonia; lithium; tert-butyl alcohol / tetrahydrofuran / 0.92 h / -65 - 15 °C / |Inert atmosphere 2.2: 0.08 h / -65 °C / |Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 1 p. 83 - 92
反应条件
zinc(II) iodide in tetrahydrofuran
12 h; Inert atmosphereReflux;
参考文献
Barney, Rocky J.; Richardson, Rebekah M.; Wiemer, David F.
Journal of Organic Chemistry, 2011 , vol. 76, # 8 p. 2875 - 2879
反应条件
{RuCl2(1-methyl-4-(1-methylethyl)benzene)}2; oxygen; caesium carbonate; SIDip*HCl in anhydrous xylene
T=130°C; 24 h;
参考文献
Zhang, Di; Pan, Changduo
Catalysis Communications, 2012 , vol. 20, p. 41 - 45
反应条件
1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -10 - 20 °C / Cooling with ice
2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C
3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C
4: di-isopropyl azodicarboxylate / triphenylphosphine / tetrahydrofuran / 20 h / 20 °C
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
6: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 22 h / 20 °C
7: TEAHCO3; tetraethyl ammonium [18]F-fluoride / acetonitrile / 0.17 h / 90 °C
View Scheme
参考文献
LANTHEUS MEDICAL IMAGING, INC.; CESATI, Richard, R.; CHEESMAN, Edward, H.; LAZEWATSKY, Joel; RADEKE, Heike, S.; CASTNER, James, F.; MONGEAU, Enrico; ZDANKIEWICZ, Dianne, D.; SIEGLER, Robert, Wilburn; DEVINE, Marybeth
Patent: WO2011/97649 A2, 2011 ;
反应条件
1: 92 percent / CBr4; PPh3 / benzene / 2 h / 0 °C
2: 72 percent / Mn / Cp2TiCl2 / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Barrero, Alejandro F.; Herrador, M. Mar; Del Moral, Jose F. Quilez; Arteaga, Pilar; Akssira, Mohammed; El Hanbali, Fadwa; Arteaga, Jesus F.; Dieguez, Horacio R.; Sanchez, Elena M.
Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 2251 - 2254
反应条件
ADMP; 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran
T=20°C; 0.166667 h;
参考文献
Kitamura, Mitsuru; Koga, Tatsuya; Yano, Masakazu; Okauchi, Tatsuo
Synlett, 2012 , vol. 23, # 9 p. 1335 - 1338
反应条件
4-methyl-3-(2,4,6-trimethylphenyl)thiazolium tetrafluoroborate; tetrabutylammomium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile
T=20°C; 24 h; Inert atmosphereElectrochemical reaction; chemoselective reaction;
参考文献
Finney, Eric E.; Ogawa, Kelli A.; Boydston, Andrew J.
Journal of the American Chemical Society, 2012 , vol. 134, # 30 p. 12374 - 12377
反应条件
rhenic(VII) acid in toluene
24 h; Reflux;
参考文献
Sousa, Sara C. A.; Bernardo, Joana R.; Fernandes, Ana C.
Tetrahedron Letters, 2012 , vol. 53, # 46 p. 6205 - 6208,4
反应条件
sodium hydrogencarbonate; [{(η5-C5Me5)IrCl}2(μ-Cl)2] in toluene
T=110°C; 17 h;
参考文献
Wetzel, Alexander; Woeckel, Simone; Schelwies, Mathias; Brinks, Marion K.; Rominger, Frank; Hofmann, Peter; Limbach, Michael
Organic Letters, 2013 , vol. 15, # 2 p. 266 - 269
