2-(4-甲基-[1,1-联苯]-4-基)乙酸合成路线 （共 5 条）
反应条件
1H-imidazole; [bis(acetoxy)iodo]benzene; Cu(AAOPD) in acetonitrile T=20°C; 4.41667 h;
参考文献
Soleymani, Reza; Taheri, Milad; HOSEYNALIBEYGl, Marziye; Daryani, Mehdi
Oriental Journal of Chemistry, 2012 , vol. 28, # 2 p. 857 - 866,10
反应条件
2C2H5NO2*Pd(2+)*2Cl(1-); potassium carbonate in water
T=20°C; Suzuki-Miyaura Coupling; 6 h; Green chemistry;
参考文献
Liu, Shiwen; Lv, Meiyun; Xiao, Daoan; Li, Xiaogang; Zhou, Xiuling; Guo, Mengping
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 25 p. 4511 - 4516
反应条件
1: (4-bromophenyl)acetyl chloride With pyridine; Si((CH2)3Si[(CH2)3SiMe2(C6H4-4)CH2OH]3)4 in tetrahydrofuran
T=20°C; Acylation;
2: p-methylphenylboronic acid With tetrakis(triphenylphosphine) palladium(0); sodium carbonate in N,N-dimethyl-formamide
T=100°C; Suzuki coupling;
3: With sodium hydroxide in tetrahydrofuran; methanol
Hydrolysis; Further stages.;
参考文献
Hovestad, Neldes J.; Ford, Allan; Jastrzebski, Johann T. B. H.; Van Koten, Gerard
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6338 - 6344
反应条件
in ammonia
Arylation; 5 h; Irradiation;
参考文献
Nwokogu; Wong; Greenwood; Wolfe
Organic letters, 2000 , vol. 2, # 17 p. 2643 - 2646
反应条件
sodium carbonate; palladium on activated charcoal in water
Suzuki reaction; 1 h; Heating;
参考文献
Lu, Gang; Franzen, Robert; Zhang, Qian; Xu, Youjun
Tetrahedron Letters, 2005 , vol. 46, # 24 p. 4255 - 4259
