5-乙基-3-甲基-1,2-恶唑-4-羧酸合成路线 （共 10 条）
反应条件
hydrogenchloride
Heating;
参考文献
Natale, N. R.; McKenna, John I.; Niou, Chorng-Shyr; Borth, Mark; Hope, Hakon
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5660 - 5666
反应条件
1: thionyl chloride / Ambient temperature
2: CHCl3 / 0 - 20 °C
3: thionyl chloride / CHCl3 / 0 - 20 °C
4: 1.) LDA / 1.) THF, -5 deg C, 30 min, 2.) THF, from -5 deg C to RT, overnight
5: 62 percent / 3 N aq. HCl / Heating
View Scheme
参考文献
Natale, N. R.; McKenna, John I.; Niou, Chorng-Shyr; Borth, Mark; Hope, Hakon
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5660 - 5666
反应条件
1: CHCl3 / 0 - 20 °C
2: thionyl chloride / CHCl3 / 0 - 20 °C
3: 1.) LDA / 1.) THF, -5 deg C, 30 min, 2.) THF, from -5 deg C to RT, overnight
4: 62 percent / 3 N aq. HCl / Heating
View Scheme
参考文献
Natale, N. R.; McKenna, John I.; Niou, Chorng-Shyr; Borth, Mark; Hope, Hakon
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5660 - 5666
反应条件
1: thionyl chloride / CHCl3 / 0 - 20 °C
2: 1.) LDA / 1.) THF, -5 deg C, 30 min, 2.) THF, from -5 deg C to RT, overnight
3: 62 percent / 3 N aq. HCl / Heating
View Scheme
参考文献
Natale, N. R.; McKenna, John I.; Niou, Chorng-Shyr; Borth, Mark; Hope, Hakon
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5660 - 5666
反应条件
1: 1.) LDA / 1.) THF, -5 deg C, 30 min, 2.) THF, from -5 deg C to RT, overnight
2: 62 percent / 3 N aq. HCl / Heating
View Scheme
参考文献
Natale, N. R.; McKenna, John I.; Niou, Chorng-Shyr; Borth, Mark; Hope, Hakon
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5660 - 5666
反应条件
n-butyllithium
1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, -78 deg C, 40 min; Yield given. Multistep reaction;
参考文献
Natale, N. R.; McKenna, John I.; Niou, Chorng-Shyr; Borth, Mark; Hope, Hakon
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5660 - 5666
反应条件
hydrogenchloride; ethanol; hydroxylamine
Erwaermen des Reaktionsprodukts mit wss. NaOH;
参考文献
Basu; Dhar
Journal of the Indian Chemical Society, 1946 , vol. 23, p. 189,191
反应条件
1: lithium aluminum hydride / tetrahydrofuran / 1.) 0 deg C, 2.) room temperature
2: 67 percent / potassium dichromate, Adogen-464 / ethyl acetate
View Scheme
参考文献
Natale, Nicholas R.; Quincy, David A.
Synthetic Communications, 1983 , vol. 13, # 10 p. 817 - 822
反应条件
n-butyllithium
1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, -78 deg C, 40 min; Yield given. Multistep reaction;
参考文献
Natale, N. R.; McKenna, John I.; Niou, Chorng-Shyr; Borth, Mark; Hope, Hakon
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5660 - 5666
反应条件
lithium aluminium tetrahydride
参考文献
Natale, N. R.; McKenna, John I.; Niou, Chorng-Shyr; Borth, Mark; Hope, Hakon
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5660 - 5666
