4-(3-氨苯基)-2-甲基-3-丁炔-2-醇合成路线 （共 12 条）
反应条件
hydrogen; cobalt polysulfide in isopropyl alcohol T=110°C; P=52476.2 Torr; 1.25 h; Autoclave;
参考文献
Castellin, Andrea; De Lucchi, Ottorino; Caporale, Andrea
Patent: US2012/95228 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tris(4-methylphenyl)-phosphine in tetrahydrofuran T=80°C; Sonogashira Cross-Coupling; 6 h; Inert atmosphereSchlenk technique; SolventReagent/catalyst;
参考文献
Caporale, Andrea; Tartaggia, Stefano; Castellin, Andrea; De Lucchi, Ottorino
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 384 - 393
反应条件
tetrabutyl ammonium fluoride; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate in tetrahydrofuran T=80°C; Inert atmosphere; Product distribution / selectivity;
参考文献
Castellin, Andrea; De Lucchi, Ottorino; Caporale, Andrea
Patent: US2012/95228 A1, 2012 ;
Location in patent: Page/Page column 6 ;
反应条件
tetrabutyl ammonium fluoride; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate in tetrahydrofuran T=80°C; 48 h; Inert atmosphere;
参考文献
EP2433931 A1, ;
Page/Page column 9 ;
反应条件
in isopropyl alcohol
参考文献
Gulf Research and Development Company
Patent: US4219679 A1, 1980 ;
反应条件
copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; triethylamine T=40°C; 2 h;
参考文献
Takalo, Harri; Kankare, Jouko; Haenninen, Elina
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988 , vol. 42, # 7 p. 448 - 454
反应条件
1: tetrabutyl ammonium fluoride / palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / tetrahydrofuran / 80 °C / Inert atmosphere 2: hydrogen / cobalt polysulfide / isopropyl alcohol / 1.25 h / 110 °C / 52476.2 Torr / Autoclave View Scheme
反应条件
1: tetrabutyl ammonium fluoride / palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / tetrahydrofuran / 80 °C / Inert atmosphere 2: hydrogen / cobalt polysulfide / isopropyl alcohol / 1.25 h / 110 °C / 52476.2 Torr / Autoclave View Scheme
反应条件
sodium hydroxide in toluene T=105 - 110°C; 4 h; Inert atmosphere;
参考文献
EP2433931 A1, ;
Page/Page column 10 ;
反应条件
sodium hydroxide in water; toluene T=90°C; 1 h; Product distribution / selectivity;
参考文献
US2008/287705 A1, ;
Page/Page column 6 ;
