1: 84 percent / DCC, DMAP / CH2Cl2 / 24 h / Ambient temperature 2: 99 percent / NaBH3CN, AcOH, HCl, H2O / tetrahydrofuran / 1 h / Ambient temperature 3: 95 percent / acetonitrile / 1.) reflux, 3 h, 2.) r.t., overnight 4: DCC, DMAP / CH2Cl2 / Ambient temperature 5: Et3N / dioxane / 12 h / Heating 6: 92 percent / KOH / ethanol / 2 h / Heating 7: 93 percent / imidazole / dimethylformamide / 24 h / Ambient temperature 9: Ph2PLi / tetrahydrofuran; hexane / 16 h / Heating 10: Bu4NF / tetrahydrofuran / Ambient temperature View Scheme

1: 88 percent / NaBH3CN, H2O, AcOH, HCl / tetrahydrofuran / 1 h / Ambient temperature 2: 98 percent / acetonitrile / 2 h / Heating 3: DCC, DMAP / CH2Cl2 / Ambient temperature 4: Et3N / dioxane / Heating 5: 90 percent / KOH / ethanol / 1 h / Heating 6: 93 percent / imidazole / dimethylformamide / 24 h / Ambient temperature 8: Ph2PLi / tetrahydrofuran; hexane / 16 h / Heating 9: Bu4NF / tetrahydrofuran / Ambient temperature View Scheme

1: 93 percent / imidazole / dimethylformamide / 24 h / Ambient temperature 3: Ph2PLi / tetrahydrofuran; hexane / 16 h / Heating 4: Bu4NF / tetrahydrofuran / Ambient temperature View Scheme

1: 84 percent / DCC, DMAP / CH2Cl2 / 24 h / Ambient temperature 2: 99 percent / NaBH3CN, AcOH, HCl, H2O / tetrahydrofuran / 1 h / Ambient temperature 3: 95 percent / acetonitrile / 1.) reflux, 3 h, 2.) r.t., overnight 4: DCC, DMAP / CH2Cl2 / Ambient temperature 5: Et3N / dioxane / 12 h / Heating 6: 92 percent / KOH / ethanol / 2 h / Heating 7: 93 percent / imidazole / dimethylformamide / 24 h / Ambient temperature 9: Ph2PLi / tetrahydrofuran; hexane / 16 h / Heating 10: Bu4NF / tetrahydrofuran / Ambient temperature View Scheme

1: 98 percent / acetonitrile / 2 h / Heating 2: DCC, DMAP / CH2Cl2 / Ambient temperature 3: Et3N / dioxane / Heating 4: 90 percent / KOH / ethanol / 1 h / Heating 5: 93 percent / imidazole / dimethylformamide / 24 h / Ambient temperature 7: Ph2PLi / tetrahydrofuran; hexane / 16 h / Heating 8: Bu4NF / tetrahydrofuran / Ambient temperature View Scheme

1: 90 percent / KOH / ethanol / 1 h / Heating 2: 93 percent / imidazole / dimethylformamide / 24 h / Ambient temperature 4: Ph2PLi / tetrahydrofuran; hexane / 16 h / Heating 5: Bu4NF / tetrahydrofuran / Ambient temperature View Scheme

2: Ph2PLi / tetrahydrofuran; hexane / 16 h / Heating 3: Bu4NF / tetrahydrofuran / Ambient temperature View Scheme

1: Ph2PLi / tetrahydrofuran; hexane / 16 h / Heating 2: Bu4NF / tetrahydrofuran / Ambient temperature View Scheme

1: 92 percent / KOH / ethanol / 2 h / Heating 2: 93 percent / imidazole / dimethylformamide / 24 h / Ambient temperature 4: Ph2PLi / tetrahydrofuran; hexane / 16 h / Heating 5: Bu4NF / tetrahydrofuran / Ambient temperature View Scheme

1: 99 percent / NaBH3CN, AcOH, HCl, H2O / tetrahydrofuran / 1 h / Ambient temperature 2: 95 percent / acetonitrile / 1.) reflux, 3 h, 2.) r.t., overnight 3: DCC, DMAP / CH2Cl2 / Ambient temperature 4: Et3N / dioxane / 12 h / Heating 5: 92 percent / KOH / ethanol / 2 h / Heating 6: 93 percent / imidazole / dimethylformamide / 24 h / Ambient temperature 8: Ph2PLi / tetrahydrofuran; hexane / 16 h / Heating 9: Bu4NF / tetrahydrofuran / Ambient temperature View Scheme