1-(2-脱氧-2-氟-beta-D-阿拉伯呋喃基)尿嘧啶合成路线 （共 12 条）
反应条件
acetic acid in methanol; water T=80°C; 6 h;
参考文献
Wako Pure Chemical Industries, Ltd.
Patent: US2008/64868 A1, 2008 ;
Location in patent: Page/Page column 6; 9 ;
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 24, # 5-7 p. 875 - 879
反应条件
hydrogenchloride; methanol; water T=45 - 60°C; 20 h; Product distribution / selectivity;
参考文献
CENTRAL GLASS COMPANY, LIMITED
Patent: EP1612213 A1, 2006 ;
Location in patent: Page/Page column 18-19 ;
反应条件
hydrogen fluoride in pyridine
参考文献
US2004/77567 A1, ;
Page/Page column 16 ;
反应条件
acetic acid T=100°C; 6 h;
参考文献
Hayakawa; Takai; Tanaka; Miyasaka; Yamaguchi
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 5 p. 1136 - 1139
反应条件
pyridine; hydrogen fluoride
参考文献
WO2003/99840 A1, ;
Page 222 ;
反应条件
ethanol; pyridinium p-toluenesulfonate T=50°C; 24 h;
参考文献
Sato; Utsumi; Maruyama; Kimura; Yamamoto; Richman
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 3 p. 595 - 598
反应条件
1: 25.1 g / 1 N aq. NaOH / methanol / 1.5 h / Ambient temperature 2: 57 percent / diethylaminosulfur trifluoride (DAST), pyridine / CH2Cl2 / 3 h / Heating 3: 66 percent / pyridinium p-toluenesulfonate (PPTS), C2H5OH / 24 h / 50 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 3 p. 595 - 598
反应条件
1: 57 percent / diethylaminosulfur trifluoride (DAST), pyridine / CH2Cl2 / 3 h / Heating 2: 66 percent / pyridinium p-toluenesulfonate (PPTS), C2H5OH / 24 h / 50 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 3 p. 595 - 598
反应条件
diethylamino-sulfur trifluoride in dichloromethane 18 h; Ambient temperature;
参考文献
Bulletin des Societes Chimiques Belges, , vol. 98, # 12 p. 937 - 942
