1: With water; sodium hydroxide in tetrahydrofuran 4 h; 2: Acidic conditions;

iodine in methanolic ammonia; diethyl ether; acetic acid

1: With F-Oct3SnH; palladium diacetate; 1,3,5,7-tetramethyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane in tetrahydrofuran T=65°C; Inert atmosphere; 2: With sodium methylate in tetrahydrofuran; methanol 3: With iodine; acetic acid Further stages;

1: NBr, AcOH 2: CH2Cl2 3: NH4OH / methanol View Scheme

1: NaI / CH2Cl2; acetonitrile / 168 h / Ambient temperature 2: 90 percent / aq. NaOH / methanol / 16 h View Scheme

1: 62.8 percent / KHF2, 50percent aq. HF / various solvent(s) / 1 h / 160 °C 2: 98 percent / HBr / CH2Cl2; acetic acid / 16 h / Ambient temperature 3: NaI / CH2Cl2; acetonitrile / 168 h / Ambient temperature 4: 90 percent / aq. NaOH / methanol / 16 h View Scheme

1: CH2Cl2 2: NH4OH / methanol View Scheme