6-氨基吡啶-2-羧酸乙酯合成路线 （共 18 条）
反应条件
triethylamine in tetrahydrofuran T=60°C; 9 h;
参考文献
Majgier-Baranowska, Helena; Li, Bing; Peet, Norton P.
Synthetic Communications, 2013 , vol. 43, # 8 p. 1173 - 1180
反应条件
sodium tetrahydroborate; calcium chloride in ethanol T=0°C; 2 h; Inert atmosphere;
参考文献
Ulrich, Sebastien; Petitjean, Anne; Lehn, Jean-Marie
European Journal of Inorganic Chemistry, 2010 , # 13 p. 1913 - 1928
反应条件
1: 100 percent / Et3N / CHCl3 / 5 h / Ambient temperature 2: 84.5 percent / DIBAL / toluene / 0.5 h / -70 °C 3: 83.8 percent / piperidine / benzene / 22 h / Heating 4: 99.5 percent / H2 / Pd / tetrahydrofuran; methanol / 5 h / 760 Torr / Ambient temperature 5: 50percent aq. NaOH / 2 h / Heating 6: benzene / 2 h / Heating 7: 96.6 percent / 50percent aq. AcOH / 0.5 h / Heating View Scheme
参考文献
Fukase, Koichi; Nakayama, Hideo; Kurosawa, Motohiro; Ikegaki, Toshiki; Kanoh, Takeshi; et al.
Journal of Carbohydrate Chemistry, 1994 , vol. 13, # 5 p. 715 - 736
反应条件
1: NEt3 / CHCl3 / 20 °C 2: DIBALH / toluene / -70 °C 3: 61 percent / aq. acetic acid / 1 h / Heating View Scheme
参考文献
Moreau, Emmanuel; Chezal, Jean-Michel; Dechambre, Caroline; Canitrot, Damien; Blache, Yves; Lartigue, Claire; Chavignon, Olivier; Teulade, Jean-Claude
Heterocycles, 2002 , vol. 57, # 1 p. 21 - 38
反应条件
1: 80 percent / NaHCO3 / ethanol; H2O / 9 h / Heating 2: 86 percent / LiAlH4 / tetrahydrofuran / 3 h View Scheme
参考文献
Chezal; Moreau; Delmas; Gueiffier; Blache; Grassy; Lartigue; Chavignon; Teulade
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6576 - 6584
反应条件
sodium hydrogencarbonate in ethanol 9 h; Heating;
参考文献
Chezal; Moreau; Delmas; Gueiffier; Blache; Grassy; Lartigue; Chavignon; Teulade
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6576 - 6584
反应条件
1: 4-(N,N-dimethlyamino)pyridine / tert-butyl alcohol; acetone / 18 h / 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 6.5 h / 0 °C / Inert atmosphere
View Scheme
参考文献
SIRTRIS PHARMACEUTICALS, INC.; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.
Patent: WO2013/59587 A1, 2013 ;
反应条件
1: 80 percent / NaHCO3 / aq. ethanol / 9 h / Heating
2: 79 percent / DIBAL-H / CH2Cl2 / 3 h / -70 °C
View Scheme
参考文献
Chezal; Moreau; Delmas; Gueiffier; Blache; Grassy; Lartigue; Chavignon; Teulade
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6576 - 6584
