potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C;

sodium hydroxide in N,N-dimethyl acetamide T=10 - 20°C; 1 h; Inert atmosphereLarge scale;

1: trichloroisocyanuric acid / dichloromethane / 23.5 h / 5 - 30 °C / |Large scale 2: sodium hydroxide / N,N-dimethyl acetamide / 1 h / 10 - 20 °C / |Inert atmosphere; |Large scale View Scheme

1: N,N,N',N,-tetramethylethylenediamine; n-butyllithium / diethyl ether 2: ammonium hydroxide / methanol 3: sodium hydroxide / N,N-dimethyl acetamide / 1 h / 10 - 20 °C / |Inert atmosphere; |Large scale View Scheme

1: sodium methylate / methanol / 4.5 h / -20 - 20 °C / |Inert atmosphere 2: acetic acid / 0.67 h / -20 - 65 °C 3: calcium chloride; hydrogenchloride / water / 4 h / 65 °C 4: sodium hydroxide / N,N-dimethyl acetamide / 1 h / 10 - 20 °C / |Inert atmosphere; |Large scale View Scheme