3-氟-2-(1H-咪唑-2-基)-嘧啶合成路线 （共 5 条）
反应条件
ammonium hydroxide in methanol
参考文献
Xu, Yuelian; Han, Bingsong; Wang, Zhe-Qing; Shaw, Kenneth R.; Chenard, Bertrand L.; Maynard, George; Xie, Linghong
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 716 - 720
反应条件
1: N,N,N',N,-tetramethylethylenediamine; n-butyllithium / diethyl ether 2: ammonium hydroxide / methanol View Scheme
参考文献
Organic Process Research and Development, , vol. 11, # 4 p. 716 - 720
反应条件
1: sodium methylate / methanol / 4.5 h / -20 - 20 °C / |Inert atmosphere 2: acetic acid / 0.67 h / -20 - 65 °C 3: calcium chloride; hydrogenchloride / water / 4 h / 65 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 11, # 4 p. 716 - 720
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide)
T=20°C;
参考文献
NEUROGEN CORPORATION
Patent: WO2005/12306 A2, 2005 ;
Location in patent: Page/Page column 50 ;
WO 2005/012306 A2
反应条件
sodium hydroxide in N,N-dimethyl acetamide
T=10 - 20°C; 1 h; Inert atmosphereLarge scale;
参考文献
Xu, Yuelian; Han, Bingsong; Wang, Zhe-Qing; Shaw, Kenneth R.; Chenard, Bertrand L.; Maynard, George; Xie, Linghong
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 716 - 720
