N-甲氧基-N-甲基苯甲酰胺合成路线 （共 140 条）
反应条件
1: 2-(4'-bromophenyl)-1,3-dioxolane With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.416667 h; Inert atmosphere; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=-78 - 20°C; 20 h; Inert atmosphere;
参考文献
Shintani, Ryo; Ito, Tomoaki; Hayashi, Tamio
Organic Letters, 2012 , vol. 14, # 9 p. 2410 - 2413
反应条件
1: n-butyl 2-pyridyl telluride With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.0833333 h; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=20°C; 20 h;
参考文献
Shilai; Uchiyama; Kondo; Sakamoto
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 2 p. 481 - 484
反应条件
naphthalenyllithium 1.) THF, -78 deg C, 2.) THF; Yield given. Multistep reaction;
参考文献
Kondo, Yoshinori; Murata, Naoko; Sakamoto, Takao
Heterocycles, 1994 , vol. 37, # 3 p. 1467 - 1468
反应条件
Yield given. Multistep reaction;
参考文献
Basha, Fatima Z.; DeBernardis, John F.
Tetrahedron Letters, 1984 , vol. 25, # 46 p. 5271 - 5274
反应条件
1: N-(2-pyridinyl)-2,2-dimethylpropanamide With n-butyllithium in hexane T=-78 - 0°C; 4 h; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=0 - 20°C; 3: With hydrogenchloride in methanol; water T=100°C; 16 h;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2005/9967 A2, 2005 ;
Location in patent: Page/Page column 28 ;
WO 2005/009967 A2
反应条件
tert.-butyl lithium 1) THF, pentane, -78 deg C, 5 min, 2) THF, -78 deg C to r.t.; Yield given. Multistep reaction;
参考文献
Selnick; Bourgeois; Butcher; Radzilowski
Tetrahedron Letters, 1993 , vol. 34, # 13 p. 2043 - 2046
反应条件
1: meta-dibromobenzene With n-butyllithium in tetrahydrofuran T=-78°C; 0.5 h; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran T=-78°C;
参考文献
Synlett, , # 8 p. 1440 - 1442
反应条件
1: 4-methyl-2-methylsulphanylpyrimidine With lithium diisopropyl amide in tetrahydrofuran; hexane T=-80 - -5°C; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=-80°C; Reflux; 3: With hydrogenchloride in tetrahydrofuran; hexane; water
参考文献
Susnik, Marko P.; Schnuerch, Michael; Mihovilovic, Marko D.; Mereiter, Kurt; Stanetty, Peter
Monatshefte fur Chemie, 2009 , vol. 140, # 4 p. 423 - 430
反应条件
1.1: tert-BuLi / tetrahydrofuran; pentane / -78 °C 1.2: 88 percent / tetrahydrofuran; pentane / -78 °C 2.1: CeCl3 / toluene; pentane / -78 °C 2.2: 93 percent / toluene; pentane / -78 °C 3.1: aq. HF 4.1: TiCl4; 2,6-lutidine / CH2Cl2 / -45 °C View Scheme
参考文献
Kummer, David A.; Brenneman, Jehrod B.; Martin, Stephen F.
Synlett, 2004 , # 8 p. 1431 - 1433
反应条件
n-butyllithium THF, 1) 0 deg C, 30 min, 2) 0 deg C, 3h; Yield given. Multistep reaction;
参考文献
Kuzma, Peter C.; Brown, Lawrence E.; Harris, Thomas M.
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2015 - 2018
