N-甲氧基-N-甲基苯甲酰胺合成路线 （共 140 条）
反应条件
9-borabicyclo[3.3.1]nonane dimer in tetrahydrofuran; N-dodecane T=25°C;
参考文献
Godjoian, Gayane; Singaram, Bakthan
Tetrahedron Letters, 1997 , vol. 38, # 10 p. 1717 - 1720
反应条件
1: ortho-dibromobenzene With n-butyllithium in tetrahydrofuran T=-78°C; 0.5 h; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran T=-78°C;
参考文献
Synlett, , # 8 p. 1440 - 1442
反应条件
1: 2-methylbenzonitrile With N,N'-dimethyl-N,N'-propyleneurea; lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; Metallation; 0.25 h; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=-78°C; Acylation; 0.5 h;
参考文献
Organic Preparations and Procedures International, , vol. 31, # 4 p. 407 - 412
反应条件
n-butyllithium; diisopropylamine 1.) THF, hexane, -78 deg C, 15 min, 2.) -78 deg C, 6 h; Yield given. Multistep reaction;
参考文献
Turner, James A.; Jacks, Wendy S.
Journal of Organic Chemistry, 1989 , vol. 54, # 17 p. 4229 - 4231
反应条件
1: 2-bromo-1-[2-(trimethylsilyl)ethynyl]benzene With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 2 h; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; pentane T=-78°C; 1 h; Further stages.;
参考文献
Iwasawa; Shido; Maeyama; Kusama
Journal of the American Chemical Society, 2000 , vol. 122, # 41 p. 10226 - 10227
反应条件
1.1: n-BuLi; isopropyl alcohol / tetrahydrofuran / 0.5 h / -78 °C 1.2: tetrahydrofuran; propan-2-ol / -78 - 0 °C 1.3: 20 percent / H2O / tetrahydrofuran; propan-2-ol / 1 h / 0 °C 2.1: 72 percent / diethyl ether / 4 h / 20 °C View Scheme
参考文献
Jeong, In Howa; Jeon, Sung Lan; Kim, Myong Sang; Kim, Bum Tae
Journal of Fluorine Chemistry, 2004 , vol. 125, # 11 SPEC. ISS. p. 1629 - 1638
反应条件
n-butyllithium 1) THF, hexane, rt, 30 min; 2) THF, hexane, -78 deg C, 15 min; Yield given. Multistep reaction;
参考文献
Ihle; Krause
Journal of Organic Chemistry, 1996 , vol. 61, # 14 p. 4810 - 4811
参考文献
Bromidge; Entwistle; Goldstein; Orlek
Synthetic Communications, 1993 , vol. 23, # 4 p. 487 - 494
反应条件
1: N-(2-pyridinyl)-2,2-dimethylpropanamide With n-butyllithium in tetrahydrofuran; hexane T=-78 - 0°C; 2.5 h; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=-78 - 20°C; 2 h;
参考文献
Takayama, Kazuhisa; Iwata, Masahiro; Hisamichi, Hiroyuki; Okamoto, Yoshinori; Aoki, Motonori; Niwa, Akira
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 8 p. 1050 - 1059
反应条件
1: 4-tert-butylacetophenone tosylhydrazone With Mes2Mg; lithium chloride in tetrahydrofuran T=40°C; Shapiro reaction; 3 h; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran T=40°C; 1 h; 3: With water-d2 in tetrahydrofuran
参考文献
Organic Letters, , vol. 14, # 9 p. 2250 - 2253
