N-甲氧基-N-甲基苯甲酰胺合成路线 （共 140 条）
反应条件
sec.-butyllithium
1.) THF, cyclohexane, -70 deg C, 10 min 2.) THF, to 0 deg C; Yield given. Multistep reaction;
参考文献
Fisher, Lawrence E.; Muchowski, Joseph M.; Clark, Robin D.
Journal of Organic Chemistry, 1992 , vol. 57, # 9 p. 2700 - 2705
反应条件
n-butyllithium in tetrahydrofuran; hexane
T=-78 - 20°C; 4 h;
参考文献
Cox, Christopher D.; Breslin, Michael J.; Mariano, Brenda J.
Tetrahedron Letters, 2004 , vol. 45, # 7 p. 1489 - 1493
反应条件
1: 1,2-dibromo-propane With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78 - 0°C;
2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane
T=-78 - 20°C;
3: With hydrogenchloride in tetrahydrofuran; hexane; water
T=0°C;
参考文献
Tanaka, Yuta; Kanai, Motomu; Shibasaki, Masakatsu
Journal of the American Chemical Society, 2010 , vol. 132, # 26 p. 8862 - 8863
反应条件
isopropylmagnesium chloride
1.) THF, r.t., 5 h, 2.) r.t., 12 h; Yield given. Multistep reaction;
参考文献
Obrecht, Daniel
Helvetica Chimica Acta, 1991 , vol. 74, # 1 p. 27 - 46
反应条件
1: 4-bromo-2-methoxy-1-chlorobenzene With magnesium in diethyl ether
Heating;
2: N-Methoxy-N-methyl-benzamide in diethyl ether
Heating;
参考文献
Gabbutt, Christopher D.; Heron, B. Mark; Instone, Alicia C.; Horton, Peter N.; Hursthouse, Michael B.
Tetrahedron, 2005 , vol. 61, # 2 p. 463 - 471
反应条件
1.1: magnesium / diethyl ether / Heating
1.2: 54 percent / diethyl ether / Heating
2.1: 41 percent / Heating
View Scheme
参考文献
Gabbutt, Christopher D.; Heron, B. Mark; Instone, Alicia C.; Horton, Peter N.; Hursthouse, Michael B.
Tetrahedron, 2005 , vol. 61, # 2 p. 463 - 471
反应条件
Bu3SnLi in tetrahydrofuran
参考文献
Paleo, M. Rita; Calaza, M. Isabel; Grana, Paula; Sardina, F. Javier
Organic Letters, 2004 , vol. 6, # 6 p. 1061 - 1063
反应条件
1: 1-methyl-2,3-indolinedione With sodium amalgam in N,N-dimethyl-formamide
T=20°C; 4 h;
2: N-Methoxy-N-methyl-benzamide in N,N-dimethyl-formamide
T=110°C; 18 h;
参考文献
Sword, Ryan; O'Sullivan, Steven; Murphy, John A.
Australian Journal of Chemistry, 2013 , vol. 66, # 3 p. 314 - 322
反应条件
1: 2-fluoro-pyridine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-70°C; 0.5 h;
2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane
T=-70 - -60°C;
参考文献
Beutner, Gregory L.; Kuethe, Jeffrey T.; Yasuda, Nobuyoshi
Tetrahedron Letters, 2009 , vol. 50, # 7 p. 781 - 784
反应条件
1: 1) n-butyllithium / 1) tetrahydrofuran, -70 deg C, 1h, 2) tetrahydrofuran up to 0 deg C
2: 42 percent / 20 h / 95 °C
3: 53 percent / sodium hydride / paraffin; dimethylformamide / 13 h / 80 °C
4: 89 percent / aq. hydrochloric acid / tetrahydrofuran / Ambient temperature
View Scheme
参考文献
Jones Jr.; Schnettler; Huber
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 3 p. 511 - 518
