5-硝基-1-(苯基甲基)-1H-咪唑-4-羧酸合成路线 （共 10 条）
反应条件
ozone; dihydrogen peroxide in formic acid; dichloromethane; water
反应条件
sodium chlorite; aminosulfonic acid in methanol; water T=20°C; 1.5 h;
参考文献
Tetrahedron Letters, , vol. 43, # 9 p. 1595 - 1596
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 4 h / 75 °C 2: 72 percent / t-BuOK / dimethylformamide; tetrahydrofuran / 0.17 h / -78 °C 3: formic acid / 18 h / 115 °C 4: NaClO2; NH2SO3H / methanol; H2O / 1.5 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 9 p. 1595 - 1596
反应条件
1: 72 percent / t-BuOK / dimethylformamide; tetrahydrofuran / 0.17 h / -78 °C 2: formic acid / 18 h / 115 °C 3: NaClO2; NH2SO3H / methanol; H2O / 1.5 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 9 p. 1595 - 1596
反应条件
1: formic acid / 18 h / 115 °C 2: NaClO2; NH2SO3H / methanol; H2O / 1.5 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 9 p. 1595 - 1596
反应条件
sodium hydroxide; potassium permanganate; sodium carbonate 1) DMF, 2) water, 36 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Heterocyclic Chemistry, , vol. 27, # 7 p. 2189 - 2196
反应条件
Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 47, # 18 p. 3457 - 3464
反应条件
1.1: CDI / tetrahydrofuran / 1 h / Heating
1.2: 68 percent / t-BuOK / 0 - 5 °C
2.1: 95 percent / Fe; HCl / ethanol / 20 h / Heating
View Scheme
参考文献
Chan; Putt; Showalter; Baker
Journal of Organic Chemistry, 1982 , vol. 47, # 18 p. 3457 - 3464
反应条件
1: 5-nitro-1-(phenylmethyl)-1H-imidazole-4-carboxylic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran
1 h; Heating;
2: nitromethane With potassium tert-butylate
T=0 - 5°C;
参考文献
Chen, Bang-Chi; Chao, Sam T.; Sundeen, Joseph E.; Tellew, John; Ahmad, Saleem
Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1595 - 1596
反应条件
potassium tert-butylate in tetrahydrofuran; nitromethane; dichloromethane; water
参考文献
Warner-Lambert Company
Patent: US4117229 A1, 1978 ;
