1: 1) acetic anhydride, pyridine; 2) conc. ammonia / 2) CH3OH 2: CF3COOH / 2 h / 60 °C 3: cc. NH3 / dioxane / 2 h / 60 °C View Scheme

1: 94 percent / K acetate, Pd/C / H2O; methanol 2: 71 percent / chromic anhydride-pyridine complex / 24 h / 40 °C 3: NH2OH / ethanol 4: 1) acetic anhydride, pyridine; 2) conc. ammonia / 2) CH3OH 5: CF3COOH / 2 h / 60 °C 6: cc. NH3 / dioxane / 2 h / 60 °C View Scheme

1: 74 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 0.5 h / Heating 2: NBS, K2CO3, benzoyl peroxide / CCl4 / 4 h / Heating 3: 1) AgCO3; 2) triethylamine / 1) H2O, dioxane, r.t., 48 h; 2) H2O, dioxane, r.t., 36 h 4: 94 percent / K acetate, Pd/C / H2O; methanol 5: 71 percent / chromic anhydride-pyridine complex / 24 h / 40 °C 6: NH2OH / ethanol 7: 1) acetic anhydride, pyridine; 2) conc. ammonia / 2) CH3OH 8: CF3COOH / 2 h / 60 °C 9: cc. NH3 / dioxane / 2 h / 60 °C View Scheme

1: NBS, K2CO3, benzoyl peroxide / CCl4 / 4 h / Heating 2: 1) AgCO3; 2) triethylamine / 1) H2O, dioxane, r.t., 48 h; 2) H2O, dioxane, r.t., 36 h 3: 94 percent / K acetate, Pd/C / H2O; methanol 4: 71 percent / chromic anhydride-pyridine complex / 24 h / 40 °C 5: NH2OH / ethanol 6: 1) acetic anhydride, pyridine; 2) conc. ammonia / 2) CH3OH 7: CF3COOH / 2 h / 60 °C 8: cc. NH3 / dioxane / 2 h / 60 °C View Scheme

1: 1) AgCO3; 2) triethylamine / 1) H2O, dioxane, r.t., 48 h; 2) H2O, dioxane, r.t., 36 h 2: 94 percent / K acetate, Pd/C / H2O; methanol 3: 71 percent / chromic anhydride-pyridine complex / 24 h / 40 °C 4: NH2OH / ethanol 5: 1) acetic anhydride, pyridine; 2) conc. ammonia / 2) CH3OH 6: CF3COOH / 2 h / 60 °C 7: cc. NH3 / dioxane / 2 h / 60 °C View Scheme

1: 68 percent / NaH / 1,2-dimethoxy-ethane / Ambient temperature 2: 75 percent / Na acetamide / 1 h / 120 °C 3: pyridine / 80 °C 4: 74 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 0.5 h / Heating 5: NBS, K2CO3, benzoyl peroxide / CCl4 / 4 h / Heating 6: 1) AgCO3; 2) triethylamine / 1) H2O, dioxane, r.t., 48 h; 2) H2O, dioxane, r.t., 36 h 7: 94 percent / K acetate, Pd/C / H2O; methanol 8: 71 percent / chromic anhydride-pyridine complex / 24 h / 40 °C 9: NH2OH / ethanol 10: 1) acetic anhydride, pyridine; 2) conc. ammonia / 2) CH3OH 11: CF3COOH / 2 h / 60 °C 12: cc. NH3 / dioxane / 2 h / 60 °C View Scheme

sodium acetate in tetrahydrofuran 0 deg C, room temperature - 12 h; Title compound not separated from byproducts;

potassium hydroxide; sodium percarbonate 6 h; Ambient temperature;

triethylamine; trichlorophosphate in acetonitrile T=65 - 95°C;

1: With water; sodium hydroxide 3 h; Reflux; 2: With ammonium acetate in water