4-(2,2,2-三氟乙基)哌嗪-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
hydrogenchloride in ethyl acetate 1.5 h;
参考文献
PIRAMED LIMITED
Patent: WO2006/46031 A1, 2006 ;
Location in patent: Page/Page column 46-47 ;
WO 2006/046031 A1
反应条件
1: With borane-THF in tetrahydrofuran
2 h; Heating / reflux;
2: With hydrogenchloride in tetrahydrofuran; water
参考文献
F.HOFFMANN-LA ROCHE AG
Patent: WO2005/110996 A1, 2005 ;
Location in patent: Page/Page column 45-46 ;
反应条件
potassium carbonate in acetonitrile
T=20°C; 16 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/41829 A1, 2004 ;
Location in patent: Page 75 ;
WO 2004/041829 A1
