4-氯-6-(3-氯丙氧基)-7-甲氧基喹唑啉合成路线 （共 10 条）
反应条件
1: 93 percent / propan-2-ol / 3 h / Heating 2: 78 percent / KI / dimethylformamide / 0.5 h / 60 °C View Scheme
参考文献
Ming, Dong Li; You, Guang Zheng; Ji, Min
Molecules, 2007 , vol. 12, # 3 p. 673 - 678
反应条件
thionyl chloride in N,N-dimethyl-formamide
7 - 8 h; Heating / reflux;
参考文献
CIPLA LIMITED; CURTIS, Philip, Anthony
Patent: WO2008/125867 A2, 2008 ;
Location in patent: Page/Page column 22-23 ;
反应条件
2,2'-azo-bisisobutyronitrile; triphenylphosphine in dichloromethane
T=20°C; 3 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/41829 A1, 2004 ;
Location in patent: Page 88-89 ;
WO 2004/041829 A1
反应条件
1: 89 percent / nitric acid; acetic acid; acetic anhydride / 6 h / 20 °C
2: 77 percent / Fe; acetic acid / methanol / 0.5 h / 50 - 60 °C
3: 92 percent / ethanol / 6 h / Heating
4: 86 percent / SOCl2 / dimethylformamide / 4 h / Heating
View Scheme
参考文献
Ming, Dong Li; You, Guang Zheng; Ji, Min
Molecules, 2007 , vol. 12, # 3 p. 673 - 678
反应条件
1: 92 percent / ethanol / 6 h / Heating
2: 86 percent / SOCl2 / dimethylformamide / 4 h / Heating
View Scheme
参考文献
Ming, Dong Li; You, Guang Zheng; Ji, Min
Molecules, 2007 , vol. 12, # 3 p. 673 - 678
反应条件
1: 77 percent / Fe; acetic acid / methanol / 0.5 h / 50 - 60 °C
2: 92 percent / ethanol / 6 h / Heating
3: 86 percent / SOCl2 / dimethylformamide / 4 h / Heating
View Scheme
参考文献
Ming, Dong Li; You, Guang Zheng; Ji, Min
Molecules, 2007 , vol. 12, # 3 p. 673 - 678
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 4 h / 70 °C
2: 89 percent / nitric acid; acetic acid; acetic anhydride / 6 h / 20 °C
3: 77 percent / Fe; acetic acid / methanol / 0.5 h / 50 - 60 °C
4: 92 percent / ethanol / 6 h / Heating
5: 86 percent / SOCl2 / dimethylformamide / 4 h / Heating
View Scheme
参考文献
Ming, Dong Li; You, Guang Zheng; Ji, Min
Molecules, 2007 , vol. 12, # 3 p. 673 - 678
反应条件
1: potassium carbonate / 60 °C
2: potassium permanganate / acetone / |Reflux
3: thionyl chloride / |Reflux
4: acetic anhydride; acetic acid; nitric acid / 0 - 5 °C
5: acetic acid; iron / methanol
6: ethanol / |Reflux
7: trichlorophosphate; triethylamine / toluene / |Reflux
View Scheme
参考文献
Zhao, Feng; Lin, Zhaohu; Wang, Feng; Zhao, Weili; Dong, Xiaochun
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5385 - 5388
反应条件
1: potassium permanganate / acetone / |Reflux
2: thionyl chloride / |Reflux
3: acetic anhydride; acetic acid; nitric acid / 0 - 5 °C
4: acetic acid; iron / methanol
5: ethanol / |Reflux
6: trichlorophosphate; triethylamine / toluene / |Reflux
View Scheme
参考文献
Zhao, Feng; Lin, Zhaohu; Wang, Feng; Zhao, Weili; Dong, Xiaochun
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5385 - 5388
反应条件
in isopropyl alcohol
3 h; Heating;
参考文献
Ming, Dong Li; You, Guang Zheng; Ji, Min
Molecules, 2007 , vol. 12, # 3 p. 673 - 678
