2′-羟基-4′-甲基苯乙酮合成路线 （共 85 条）
反应条件
1: aq. NaOH
2: aq. NaOCl
3: Br2 / Irradiation
View Scheme
参考文献
Julia,M.; Chastrette,F.
Bulletin de la Societe Chimique de France, 1962 , p. 2255 - 2261
反应条件
ammonia in methanol
T=20°C; Cooling with ice;
参考文献
Nguyen, Thanh Binh; Bousserouel, Hadjira; Wang, Qian; Gueritte, Francoise
Organic Letters, 2010 , vol. 12, # 20 p. 4705 - 4707
参考文献
Hoshino, Yukio; Oohinata, Toshinori; Takeno, Noboru
Bulletin of the Chemical Society of Japan, 1986 , vol. 59, # 7 p. 2351 - 2352
反应条件
1: aq. NaOH
2: aq. NaOCl
3: Br2, AlCl3 / CCl4 / Irradiation
4: HCl
5: (i) hexamethylenetetramine, (ii) aq. AcOH
View Scheme
参考文献
Julia,M.; Chastrette,F.
Bulletin de la Societe Chimique de France, 1962 , p. 2255 - 2261
反应条件
hydrogenchloride; sodium; acetic acid
1.) ether, RT, 15 h, ether, 100 deg C, 0.5 h; Multistep reaction;
参考文献
Kataoka, Ken-ichiro; Shiota, Tatsuki; Takeyasu, Takumi; Mochizuki, Tsutomu; Taneda, Keiko; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 16 p. 3174 - 3186
反应条件
potassium carbonate; potassium iodide in acetonitrile
T=70°C;
参考文献
Wang, Chenying; Liu, Jikai; Ji, Yanhua; Zhao, Jingfeng; Li, Liang; Zhang, Hongbin
Organic Letters, 2006 , vol. 8, # 12 p. 2479 - 2481
反应条件
potassium carbonate in tetrahydrofuran; N,N-dimethyl-formamide
20 h; Reflux;
参考文献
Breyer, Sandra; Effenberger-Neidnicht, Katharina; Schobert, Rainer
Journal of Organic Chemistry, 2010 , vol. 75, # 18 p. 6214 - 6218
反应条件
1: N,N-dimethyl-formamide With bis(trichloromethyl) carbonate in 1,2-dichloro-ethane
T=0 - 20°C;
2: 4-methyl-2-hydroxyacetophenone in 1,2-dichloro-ethane
T=0 - 20°C; 4.5 h; Further stages.;
参考文献
Su; Li; Zhao
Organic Preparations and Procedures International, 2007 , vol. 39, # 5 p. 495 - 502
反应条件
1: aq. NaOH
2: aq. NaOCl
3: H2SO4
4: Br2 / acetic acid
View Scheme
参考文献
Julia,M.; Chastrette,F.
Bulletin de la Societe Chimique de France, 1962 , p. 2255 - 2261
反应条件
1: With sodium hydride in tetrahydrofuran
5 h;
2: With toluene-4-sulfonic acid in benzene
8 h; Reflux;
参考文献
Seth, Saikat Kumar; Sarkar, Debayan; Kar, Tanusree
CrystEngComm, 2011 , vol. 13, # 14 p. 4528 - 4535
