4'-氯-2'-羟基苯乙酮合成路线 （共 21 条）
反应条件
AlCl3, aluminium chloride T=140°C; 2 h; Heating / reflux;
参考文献
SmithKline Beecham Corporation
Patent: US6353116 B1, 2002 ;
Location in patent: Page column 22 ;
US 6353116 B1
反应条件
boron tribromide in dichloromethane T=0 - 20°C; 1.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 22 p. 6569 - 6584
反应条件
Co(Salpr); oxygen in ethanol 0.166667 h; Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 25, # 50 p. 5805 - 5808
反应条件
1: in toluene T=40°C; 2: With aluminium trichloride in toluene T=80°C; Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 9 p. 2108 - 2116
反应条件
1: tetrahydrofuran; diethyl ether / 16 h / -78 - 20 °C 2: boron tribromide / CH2Cl2 / 1.5 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 22 p. 6569 - 6584
反应条件
1.1: oxalyl chloride; DMF / CH2Cl2 / 1.5 h / 0 - 20 °C 1.2: diisopropylethylamine / CH2Cl2 / 15 h / 20 °C 2.1: tetrahydrofuran; diethyl ether / 16 h / -78 - 20 °C 3.1: boron tribromide / CH2Cl2 / 1.5 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 22 p. 6569 - 6584
反应条件
1: 73.3 percent / pyridine / CH2Cl2 / 5 °C 2: 55 percent / aluminium chloride / 2 h / 140 °C View Scheme
参考文献
Pharmacy and Pharmacology Communications, , vol. 5, # 5 p. 323 - 329
反应条件
aluminium trichloride T=150°C;
参考文献
Annali di Chimica (Rome, Italy), , vol. 41, p. 421,423
Journal of the Indian Chemical Society, , vol. 36, p. 784
反应条件
(i) CF3CO2Na, CF3CO2H, MeNO2, (electrochemical oxidation), (ii) aq. NaHCO3; Multistep reaction;
参考文献
Synthesis, , p. 468 - 469
反应条件
sodium hydride in toluene T=110°C;
参考文献
Peng, Shiyong; Wang, Lei; Huang, Jiayao; Sun, Shaofa; Guo, Haibing; Wang, Jian
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 13 p. 2550 - 2557
