4'-氯-2'-羟基苯乙酮合成路线 （共 21 条）
反应条件
potassium hydroxide in ethanol; water
参考文献
Beiersdorf Aktiengesellschaft
Patent: US4265903 A1, 1981 ;
反应条件
1: aq. NaOH / Heating 2: NaOAc; Ac2O / 110 °C View Scheme
参考文献
Mylari, Banavara L.; Armento, Sandra J.; Beebe, David A.; Conn, Edward L.; Coutcher, James B.; Dina, Michael S.; O'Gorman, Melissa T.; Linhares, Michael C.; Martin, William H.; Oates, Peter J.; Tess, David A.; Withbroe, Gregory J.; Zembrowski, William J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 20 p. 6326 - 6339
反应条件
1: 25 percent / conc. HCl / propan-2-ol / 5 h / Heating 2: 35 percent / 0.02 M aq. KOH / H2O / 0.25 h / 35 °C View Scheme
参考文献
Cox, Brian; Waigh, Roger D.
Synthesis, 1989 , # 9 p. 709 - 710
反应条件
1: With sodium ethanolate in ethanol T=40°C; 1 h; 2: With hydrogenchloride; acetic acid in water T=90°C; 4 h;
参考文献
Lynch, John K.; Collins, Christine A.; Freeman, Jennifer C.; Gao, Ju; Iyengar, Rajesh R.; Judd, Andrew S.; Kym, Philip R.; Mulhern, Mathew M.; Sham, Hing L.; Souers, Andrew J.; Zhao, Gang; Wodka, Dariusz
Patent: US2005/209274 A1, 2005 ;
Location in patent: Page/Page column 21-22 ;
US 20050209274 A1
反应条件
1: sodium hydroxide / ethanol / 20 °C
2: copper(l) iodide; oxygen / 48 h / 50 °C / 760.05 Torr / Ionic liquid
View Scheme
参考文献
Du, Zhiyun; Ng, Huifen; Zhang, Kun; Zeng, Huaqiang; Wang, Jian
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 6930 - 6933
反应条件
anhydrous sodium benzoate
T=220°C;
参考文献
Cramer; Elschnig
Chemische Berichte, 1956 , vol. 89, p. 1,10
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
The Boots Company PLC
Patent: US5547972 A1, 1996 ;
参考文献
Sen; Tiwari
Journal of the Indian Chemical Society, 1952 , vol. 29, p. 419,421,423
参考文献
Goethals, G.; Nadio, L.; Uzan, R.
Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 1981 , vol. 37, # 3 p. 199 - 204
反应条件
magnesium oxide in ethanol
Claisen-Schmidt condensation; 30 h; Heating;
参考文献
Choudary; Ranganath; Yadav, Jagajit; Lakshmi Kantam
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1369 - 1371
