iodine; sodium hydrogencarbonate in tetrahydrofuran; water T=20°C; 140 h;

1: sulfuric acid / 8 h / 90 °C 2: iodine; sodium hydrogencarbonate / tetrahydrofuran; water / 140 h / 20 °C View Scheme

bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine in ethylene glycol dimethyl ether Sonogashira coupling;