3,3-二甲基-1,5-二氧杂螺[5.5]十一烷-9-酮合成路线 （共 11 条）
反应条件
potassium peroxymonosulfate; sodium 2-iodobenzenesulfonate; sodium sulfate in ethyl acetate T=70°C; 8 h;
参考文献
National University Corporation Nagoya University
Patent: EP2085373 A1, 2009 ;
Location in patent: Page/Page column 12; 14-15 ;
反应条件
sulfuric acid in water T=90°C;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2007/48717 A1, 2007 ;
Location in patent: Page/Page column 23 ;
反应条件
sodium hydrogencarbonate in water; toluene; acetonitrile
参考文献
Eli Lilly and Company
Patent: US4587351 A1, 1986 ;
反应条件
HOF* CH3CN in dichloromethane T=0°C; 0.0166667 h;
参考文献
Carmeli, Mira; Rozen, Shlomo
Tetrahedron Letters, 2006 , vol. 47, # 5 p. 763 - 766
反应条件
acetic acid; zinc T=-17°C; 1.5 h;
参考文献
Jefford, Charles W.; Rossier, Jean-Claude; Boukouvalas, John
Heterocycles, 1989 , vol. 28, # 2 p. 673 - 676
反应条件
hydrogenchloride in tetrahydrofuran; water 26 h; Ambient temperature;
参考文献
Synthetic Communications, , vol. 19, # 5and6 p. 745 - 754
反应条件
1: 90 percent / p-toluenesulfonic acid / benzene / 4.6 h / Heating 2: 81 percent / CrO3, 3,5-dimethylpyrazole / CH2Cl2 / 0.17 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 3 p. 341 - 346
反应条件
1: 90 percent / p-toluenesulfonic acid / benzene / 4.6 h / Heating 2: 81 percent / CrO3, 3,5-dimethylpyrazole / CH2Cl2 / 0.17 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 3 p. 341 - 346
反应条件
sulfuric acid in water 41 h; extraction by hexane; Yield given;
参考文献
Babler, James H.; Spina, Kenneth P.
Synthetic Communications, 1984 , vol. 14, # 1 p. 39 - 44
反应条件
1.1: methanol 2.1: hydrogenchloride / water / 65 - 70 °C 2.2: 15 °C / pH 10 View Scheme
参考文献
ORCHID CHEMICALS AND PHARAMCEUTICALS LIMITED; REGURI, Buchi Reddy; UPPARAPALLI, Sampathkumar; KUNCHITHAPATHAM, Thirumurugan; SAMBASHIVAM, Thiyagarajan; MUNUSAMY, Suresh
Patent: WO2012/147020 A1, 2012 ;
