6-溴-1,2,4-噻嗪-3-胺合成路线 (共 2 条)
反应条件
1: With N-bromosuccinmide in acetonitrile T=0 - 20°C; 2: With sodium carbonate in ethyl acetate; acetonitrile T=0°C; 0.166667 h; Cooling with ice;
参考文献
US2011/212967 A1, ;
Page/Page column 10 ;
反应条件
caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane; water T=120°C; 4 h; Microwave irradiationInert atmosphere;
参考文献
VIVALIS; CIAPETTI, Paola; TROUCHE, Nathalie; VENKATA PITHANI, Subhash; GUEDAT, Philippe; BERECIBAR, Amaya
Patent: WO2012/93174 A1, 2012 ;
Location in patent: Page/Page column 64 ;
WO 2012/093174 A1