2-羟基-1-吡咯烷羧酸苄酯合成路线 （共 17 条）
反应条件
lithium triethylborohydride in tetrahydrofuran
T=-78°C; 1 h;
参考文献
Piperno, Anna; Carnovale, Caterina; Giofr, Salvatore V.; Iannazzo, Daniela
Tetrahedron Letters, 2011 , vol. 52, # 51 p. 6880 - 6882
反应条件
iodine in methanol; dichloromethane
T=20°C; 6.5 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2005/12249 A2, 2005 ;
Location in patent: Page/Page column 39-40 ;
WO 2005/012249 A2
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane
T=-78 - 20°C; Swern oxidation;
参考文献
Delcros, Jean-Guy; Tomasi, Sophie; Carrington, Simon; Martin, Benedicte; Renault, Jacques; Blagbrough, Ian S.; Uriac, Philippe
Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5098 - 5111
反应条件
lead(IV) acetate in benzene
T=20°C; modified Hunsdiecker reaction; 48 h;
参考文献
Kaname; Mashige; Yoshifuji
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 5 p. 531 - 536
反应条件
[bis(acetoxy)iodo]benzene; iodine in dichloromethane
T=26°C; 2.5 h;
参考文献
Boto, Alicia; Hernandez, Rosendo; Montoya, Adriana; Suarez, Ernesto
Tetrahedron Letters, 2004 , vol. 45, # 7 p. 1559 - 1563
反应条件
1: (S)-2-hydroxymethyl-1-pyrrolidine carboxylic acid phenylmethyl ester With [bis(acetoxy)iodo]benzene; iodine in dichloromethane
T=26°C; 2.5 h;
2: allyl-trimethyl-silane With boron trifluoride diethyl etherate in dichloromethane
T=26°C; 4 h;
参考文献
Boto, Alicia; Hernandez, Rosendo; Montoya, Adriana; Suarez, Ernesto
Tetrahedron Letters, 2004 , vol. 45, # 7 p. 1559 - 1563
反应条件
[bis(acetoxy)iodo]benzene; iodine in acetonitrile
T=20°C; Decarboxylation; iodination; 5 h;
参考文献
Boto; Hernandez; De Leon; Suarez
Journal of Organic Chemistry, 2001 , vol. 66, # 23 p. 7796 - 7803
反应条件
sodium hydrogencarbonate; sodium carbonate; 3-chloro-benzenecarboperoxoic acid in 1,4-dioxane
T=20°C; 24 h;
参考文献
Kaname; Mashige; Yoshifuji
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 5 p. 531 - 536
反应条件
sodium hydrogencarbonate; sodium carbonate; 3-chloro-benzenecarboperoxoic acid in 1,4-dioxane
T=20°C; 24 h;
参考文献
Kaname; Mashige; Yoshifuji
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 5 p. 531 - 536
反应条件
1: 95 percent / aq. NaHCO3 / tetrahydrofuran / 0 - 26 °C
2: 67 percent / (diacetoxyiodo)benzene; iodine / CH2Cl2 / 2.5 h / 26 °C
View Scheme
参考文献
Boto, Alicia; Hernandez, Dacil; Hernandez, Rosendo; Montoya, Adriana; Suarez, Ernesto
European Journal of Organic Chemistry, 2007 , # 2 p. 325 - 334
