1: n-butyl-magnesium chloride With diethylzinc; (R)-2,2'-dihydroxy-1,1'-binaphthyl in tetrahydrofuran; 1,2-dichloro-ethane
T=-40 - 20°C; 1 h;
2: trifluoro-pyruvic acid ethyl ester in tetrahydrofuran; 1,2-dichloro-ethane
T=-40°C; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Gosselin, Francis; Britton, Robert A.; Mowat, Jeffrey; O'Shea, Paul D.; Davies, Ian W.
Synlett, 2007 , # 14 p. 2193 - 2196
