(E)-5-(2-溴乙烯基)尿嘧啶合成路线 （共 8 条）
反应条件
in N-methyl-acetamide; water
参考文献
Rega Instituut VZW; University of Birmingham
Patent: US4424211 A1, 1984 ;
反应条件
N-bromosuccinmide; potassium acetate in water T=90°C;
参考文献
Eger; Jalalian; Schmidt
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 1 p. 211 - 218
反应条件
1: 78 percent / pyridine, piperidine / 2 h / Heating 2: 81 percent / N-bromosuccinimide, potassium acetate / H2O / 90 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1665 - 1670
反应条件
potassium carbonate in aq. phosphate buffer T=20°C; pH=10; 3 h; Enzymatic reaction; Reagent/catalyst;
参考文献
Serra, Immacolata; Bavaro, Teodora; Cecchini, Davide A.; Daly, Simona; Albertini, Alessandra M.; Terreni, Marco; Ubiali, Daniela
Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 95, p. 16 - 22
反应条件
potassium carbonate in aq. phosphate buffer T=20°C; pH=10; 3 h; Enzymatic reaction; Reagent/catalyst;
参考文献
Serra, Immacolata; Bavaro, Teodora; Cecchini, Davide A.; Daly, Simona; Albertini, Alessandra M.; Terreni, Marco; Ubiali, Daniela
Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 95, p. 16 - 22
反应条件
1: 84 percent / hexamethyldisilazane / 1 h / Heating 2: 1,2-dichloro-ethane / 8 h / 20 °C 3: 94 percent / 0.1M sodium methoxide / methanol / 24 h / 22 °C View Scheme
参考文献
Barr, Philip J.; Jones, A. Stanley; Verhelst, Gabriel; Walker, Richard T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1665 - 1670
反应条件
1: chlorotrimethylsilane / Heating
2: 1.) acetonitrile, 0 degC, 2.) 0 degC to R.T. 2 h
3: 91 percent / NH3 / methanol / 5 h / Ambient temperature
View Scheme
参考文献
Robins; Hatfield
Canadian Journal of Chemistry, 1982 , vol. 60, # 5 p. 547 - 553
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
T=50 - 55°C; 3 h;
参考文献
Eger; Jalalian; Schmidt
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 1 p. 211 - 218
