2-(6-甲氧基-2-萘)-2-甲基丙酸合成路线 （共 3 条）
反应条件
anhydrous potassium trimethylsilanolate in tetrahydrofuran
2 h; Reflux;
参考文献
Windsor, Matthew A.; Hermanson, Daniel J.; Kingsley, Philip J.; Xu, Shu; Crews, Brenda C.; Ho, Winnie; Keenan, Catherine M.; Banerjee, Surajit; Sharkey, Keith A.; Marnett, Lawrence J.
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 9 p. 759 - 763
反应条件
1.1: sulfuric acid / 2 h / |Reflux
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere
2.2: 0.5 h / -78 - 0 °C / |Inert atmosphere
2.3: 1 h / 0 - 20 °C / |Inert atmosphere
3.1: anhydrous potassium trimethylsilanolate / tetrahydrofuran / 2 h / |Reflux
View Scheme
参考文献
Windsor, Matthew A.; Hermanson, Daniel J.; Kingsley, Philip J.; Xu, Shu; Crews, Brenda C.; Ho, Winnie; Keenan, Catherine M.; Banerjee, Surajit; Sharkey, Keith A.; Marnett, Lawrence J.
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 9 p. 759 - 763
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere
1.2: 0.5 h / -78 - 0 °C / |Inert atmosphere
1.3: 1 h / 0 - 20 °C / |Inert atmosphere
2.1: anhydrous potassium trimethylsilanolate / tetrahydrofuran / 2 h / |Reflux
View Scheme
参考文献
Windsor, Matthew A.; Hermanson, Daniel J.; Kingsley, Philip J.; Xu, Shu; Crews, Brenda C.; Ho, Winnie; Keenan, Catherine M.; Banerjee, Surajit; Sharkey, Keith A.; Marnett, Lawrence J.
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 9 p. 759 - 763
